摘要
目的探讨新辅助化疗联合人工关节置换术治疗四肢恶性骨肿瘤的疗效及对血清肿瘤标记物水平、免疫功能的影响。方法纳入自2013-06—2016-10诊治的300例四肢恶性骨肿瘤,采用新辅助化疗联合人工关节置换术治疗150例(观察组),采用单纯人工关节置换术治疗150例(观察组)。比较2组血清肿瘤标记物、免疫功能指标及日常生活能力量表(ADL)评分。结果 300例均获得随访,随访时间6~12(7.58±4.02)个月。2组术后6个月的ADL评分较术前明显增加,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组术后6个月的血清癌胚抗原(CEA)、癌胚抗原-125(CA125)低于对照组,免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论新辅助化疗联合人工关节置换术治疗四肢恶性骨肿瘤疗效确切,可有效降低患者血清肿瘤标记物水平,提高患者免疫功能和生活质量。
Objective To investigate the curative effect of neoadjuvant chemotherapy combined with artificial joint replacement in the treatment of malignant bone tumors of extremities and its effect on levels of serum tumor markers and immune function. Methods Three hundred patients with malignant bone tumors of extremities who were diagnosed and treated in our hospital from June 2013 to October 2016 were selected. One hundred and fifty cases treated by neoadjuvant chemotherapy combined with artificial joint replacement were included in the observation group while the other 150 cases treated by artificial joint replacement were included in the control group. Serum tumor markers, mmune function indexes, score of activities of daily living （ADL） were compared between the two groups. Results All of the 300 patients were followed up for 6-12 months, an average of （7.58＋4.02） months. ADL scores of the two groups were increased obviously at 6 months after operation, and the scores of observation group were higher than those of the control group （P 〈0 05）. Levels of serum carcinoembryonie antigen （CEA） and carcinoembryonic antigen -125 （CA125） in the observation group at 6 months after operation were lower ＇than those in the control group, while levels of immunoglobulin G （IgG）, immunoglobulin A （IgA） and immunoglobulin M （IgM） were higher than those in the control group （P 〈0.05）. The incidence of complications in the observation group was lower than that in the control gi＇oup （P 〈0.05）. Conclusion Neoadjuvant chemotherapy combined with artificial joint replacement is effective in the treatment of patients with malignant bone tumors of extremities. It can effectively reduce levels of serum tumor markers and improve the immune function and quality of life of patients.
出处
《中国骨与关节损伤杂志》
2018年第1期39-42,共4页
Chinese Journal of Bone and Joint Injury
基金
四川省卫生和计划生育委员会科研课题(17PJ180)
关键词
四肢恶性骨肿瘤
人工关节置换术
新辅助化疗
血清肿瘤标记物
免疫功能
生活质量
Malignant bone tumors of extremities
Artificial joint replacement
Neoadjuvant chemotherapy
Serum tumor markers
Immune function
Quality of life
