摘要
目的探讨亚低温支持联合静脉泵注钙离子拮抗剂对重度颅脑损伤术后脑血管痉挛的影响。方法选取我院收治的206例重度颅脑损伤患者,随机分为联合组(106例)和对照组(100例)。术后均用医疗控温毯和冰帽行脑部亚低温支持,联合组在此基础上用静脉注射泵推注10 mg/50 m L尼莫地平注射液。结果术后3 d、5 d、7 d、14 d,联合组大脑中动脉平均血流速均明显低于对照组(P<0.05)。两组患者术后脑血管痉挛程度比较有统计学差异(P<0.05)。联合组术后脑血管痉挛发生率明显低于对照组(P<0.05)。术后6个月,联合组的Ⅴ级比率明显高于对照组,伤残率明显低于对照组(P均<0.05)。结论术后对重度颅脑损伤患者给予亚低温支持联合静脉泵注尼莫地平,可有效抑制急性高灌注,降低脑血管痉挛程度和发生率。
Objective To study the effect of mild hypothermia support combined with intravenous infusion of calcium antagonists on cerebral vasospasm after severe traumatic brain injury surgery. Methods 206 cases of patients with severe traumatic brain injury admitted to our hospital were selected and randomly divided into combined group （106 cases） and control group （100 cases）. Patients received mild hypothermia support by using a medical temperature control blanket and an ice cap. On this basis, the combined group was injected with 10 mg/50 mL of nimodipine by intravenous pump. Results 3 d, 5 d, 7 d and 14 d after surgery, the average blood flow velocity of middle cerebral artery of combined group was significantly lower than that of control group （P 〈0.05）. Statistical difference was found in the cerebral vasospasm degree between two groups （P 〈0.05）. The incidence of cerebral vasospasm of combined group was significantly lower than that of control group （P〈0.05）. 6 months after operation, the V rate of combined group was significantly higher than that of control group, and the disability rate was significantly lower than that of control group （P〈0.05）. Conclusions Mild hypothermia support combined with intravenous infusion of nimodipine in patients with severe traumatic brain injury after surgery can effectively inhibit the acute high perfusion, and reduce the degree and incidence of cerebral vasospasm.
出处
《临床医学工程》
2018年第1期81-82,共2页
Clinical Medicine & Engineering
关键词
重度颅脑损伤
亚低温
尼莫地平
脑血管痉挛
预后
Severe traumatic brain injury
Mild hypothermia
Nimodipine
Cerebral vasospasm
Prognosis
