摘要
目的:观察清胰化瘀解毒方治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的临床疗效及其对患者免疫功能的影响。方法:选取2016年1月至2017年1月本院收治的120例SAP患者为研究对象,随机分为观察组和对照组,每组各60例。对照组给予常规西药进行治疗,观察组在对照组基础上给予清胰化瘀解毒方。比较两组患者临床症状缓解情况及临床疗效,检测两组患者治疗前后免疫球蛋白(Ig G、Ig A、Ig M)及T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)及血淀粉酶水平。结果:观察组腹痛、腹胀、肠鸣音、排气、排便、发热缓解时间均显著性短于对照组,差异具有统计学意义(P<0.05)。观察组有效率为91.67%,对照组有效率为70.00%,两组患者临床疗效比较,差异具有统计学意义(P<0.05)。两组患者治疗后CD3+、CD4+、CD8+、CD4+/CD8+、Ig A、Ig M、Ig G水平高于治疗前,且观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后血淀粉酶水平低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论:清胰化瘀解毒方可以显著改善重症急性胰腺炎患者的临床症状,临床疗效好,且可提高患者的免疫功能。
Objective ：To observe the clinical curative effect and the influence of Qingyi Huayu Jiedu Decoction（QYHYJDD） on immune function of patients with severe acute pancreatitis （SAP）. Methods：One hundred and twenty patients with SAP who were treated in our hospital between January 2016 and January 2017 were chosen as the research subjects,and randomly divided into the observation group and the control group, with 60 cases in each group. The ones in the control group were given routine Western medicine tl^atment,while the ones in the observation group were added QYHYJI）D based on the treatment of the control group. Then remission of clinical symptoms and the clinical curative effects of the two groups were compared. The levels of immunoglobu- lin （ IgG, IgA, [gM） and T cell subsets （ CD3 ＋ , CD4＋ , CD8 ＋ , CD4 ＋/CD8 ＋ ） and serum amylase level before and after the treat- ment in two groups were detected. Results ：The abdominal pain and distension, bowel sound ,exhaust and defecation ,fever relieving time in the observation group were significantly shorter than those in the control group, all the differences were statistically signifi- cant （P 〈0.05）. The effective rates of the observation group and the eontrol group were 91.67% and 70% respectively. The difference between the two groups was statistically significal （ P 〈 0.05 ）. After the treatment, the levels of CD3 ＋ ,CD4 ＋ , CD8 ＋ , CD4 ＋/CD8 ＋ ,]gA,IgM and IgG in the two groups were higher than those before the treatment, and the observation group was higher than that in the control group, and all the differences were statistically significant （ P 〈 0.05 ）. After the treatment, the blood amylase water in the two groups was lower than that before the treatment,and the observation group was lower than the con- trol group,and the difference was statistically significant （P 〈 0.05 ）. Conclusion： QYI-IYJDD has a remarkable clinical curative effect on patients with SPA,can significantly improve the clinical symptoms of patients and their immune functions.
出处
《河南中医》
2018年第1期100-102,共3页
Henan Traditional Chinese Medicine
基金
上海中医药事业发展3年行动计划项目(编号:ZYSNXDCC-YJXYY)
关键词
重症急性胰腺炎
清胰化瘀解毒方
免疫功能
免疫球蛋白
T细胞亚群
血淀粉酶水平
severe acute pancreatitis
Qingyi Huayu Jiedu Deeoction（ QYHYJDD ）
immune function
immunoglobulin
T cell subsets
serum anylase level
