摘要
人类染色体3p21．3区域被证实有与包括鼻咽癌在内的恶性肿瘤发生、发展密切相关的多个抑癌基因集聚。如BLU基因，在鼻咽癌中表现为表达下调，而在其他肿瘤则表现为启动子甲基化，体外试验或动物实验证实其具有抑制肿瘤生长作用，但具体的抑癌机制尚未完全阐明。本文就3p21．3区域及其中抑癌基因BLu在鼻咽癌的研究进展做一综述。
Human chromosome 3p21.3 was confirmed to be a tumor suppressor gene （TSG） cluster that contains several TSGs associated with the development of many human tumors, including nasopharyngeal carcinoma（NPC）. BLU was one of TSGs mapped in this region and has been repeatedly reported to be involved in the development of NPC and many other tumors. The expression of BLU is frequently down regulated in NPC and many other tumors due to promoter hypermethylation. Functional evidence shows that the BLU gene inhibits tumor growth in animal assays, but the detailed molecular mechanism responsible for this is still not well understood. In this paper, the related literatures and research reports in recent years were reviewed.
出处
《国际耳鼻咽喉头颈外科杂志》
2018年第1期8-11,共4页
International Journal of Otolaryngology-Head and Neck Surgery
关键词
鼻咽肿瘤
染色体
抑癌基因
Nasopharyngeal Neoplasms
Chromosomes
tumor supressor genes
