摘要
烟酰胺腺嘌呤二核苷磷酸(nico-tinamide adenine dinucleotide phosphate,NADPH)氧化酶最早发现于吞噬细胞的呼吸爆发,后来发现NADPH氧化酶也表达于上皮细胞、内皮细胞等非吞噬细胞中。NADPH氧化酶与活性氧(reactive oxygen species,ROS)的产生、细胞内氧化还原反应、氧化应激及信号传导密切相关,与心血管系统疾病、呼吸系统疾病等慢性病的发生发展也有一定关联。本文就NADPH氧化酶与常见呼吸道黏膜炎性疾病的研究进展做简要综述。
Nico-tinamide adenine dinucleotide phosphate( NADPH) oxidase was first found in the respiratory burst of phagocytic cells. It was also found that NADPH oxidase was expressed in epithelial cells,endothelial cells and other non-phagocytic cells. NADPH oxidase is closely related with reactive oxygen species( ROS) production,intracellular redox reaction,oxidative stress and signal transduction. It also has certain correlation with the occurrence and development of manychronic diseases,such as cardiovascular diseases,respiratory diseases and so on. This article briefly reviews the research progress of NADPH oxidase in inflammatory diseases of respiratory tract.
出处
《首都医科大学学报》
CAS
北大核心
2018年第1期69-73,共5页
Journal of Capital Medical University
基金
国家自然科学基金重点国际合作项目(81420108009)
国家自然科学基金重点项目(81630023)
国家自然科学基金面上项目(81570894)
教育部长江学者和创新团队发展计划(IRT13082)
北京市百千万人才工程资助项目(2016)
北京市自然科学基金面上项目(7172053)
北京市卫生系统高层次卫生技术人才(2009-2-007
2011-3-039
2011-3-043
2014-3-018)
北京市医院管理局使命人才计划(SML20150203)
北京市科技项目统筹课题(Z171100000117002)~~
关键词
烟酰胺腺嘌呤二核苷磷酸氧化酶
活性氧
氧化应激
变应性鼻炎
慢性鼻-鼻窦炎
哮喘
慢性阻塞性肺疾病
nicc- t inamide adenine dinucleot ide phosphate (NADPH) oxidase,reactive oxygen species ( R0S),oxidative st ress,a llergic rhini tis ( AR)
chronic rhinosinusit is ( CRS)
asthma
chronic obstruct ive pulmonary disea se ( C0PD)