摘要
目的探讨重组组织型纤溶酶原激活剂(Rtpa)溶栓联合介入术治疗急性脑梗死临床效果。方法选取南宁市第一人民医院155例急性脑梗死患者,按照随机数字表法分组,对照组77例给予Rtpa溶栓治疗,观察组78例给予Rtpa溶栓+介入术治疗,观察比较2组神经功能缺损(NIHSS)评分及临床疗效,统计并发症发生率及生活质量(SS-QOL)评分。结果治疗1周后观察组NIHSS评分低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为88.46%(69/78),高于对照组75.32%(58/77),差异有统计学意义(P<0.05);观察组并发症发生率为6.41%(5/78),对照组为3.90%(3/77),组间比较差异无统计学意义(P>0.05);治疗1周后观察组SS-QOL评分高于对照组,差异具有统计学意义(P<0.05)。结论 Rtpa溶栓与介入术联合治疗急性脑梗死效果较佳,有助于受损神经功能的修复,且可提高患者生活质量,安全性高。
Objective To investigate the clinical effect of recombinant tissue plasminogen activator （Rtpa） thrombolysis combined with interventional therapy in the treatment of acute cerebral infarction. Methods Totally 155 patients with acute cere- bral infarction in our hospital were selected. They were randomly divided into two groups. The control group （77 cases） received Rtpa thrombolysis,and the observation group （78 cases） received Rtpa thrombolysis combined with interventional therapy. The neurological deficits （NIHSS） score and clinical efficacy were observed and compared between the two groups. And the complica- tion rate and the quality of life （SS-QOL） score were calculated between the two groups. Results The score of NIHSS in the ob- servation group was lower than that of the control group after 1 week＇s treatment, and the difference was statistically significant （P〈0. 05）. The total effective rate of the observation group was 88. 46% （69/78） ,which was significantly higher than that of the control group 75.32% （58/77） （P〈0.05）. The complication rate was 6.41% （5/78） in the observation group and 3. 90% （3/ 77） in the control group. There was no significant difference between the two groups （P〉0. 05）. After one-week treatment, the SS-QOL score of the observation group was higher than that of the control group, the difference was statistically significant （P〈 0.05）. Conclusion Rtpa thrombolysis combined with interventional therapy is effective in the treatment of acute cerebral infarc- tion, which is helpful for the repair of damaged neurologic function and can improve the quality of life with high safety.
出处
《中国实用神经疾病杂志》
2017年第23期71-74,共4页
Chinese Journal of Practical Nervous Diseases
基金
南宁市科学研究与技术开发计划(20163142)
关键词
急性脑梗死
Rtpa溶栓
介入术
安全性
生活质量
Acute cerebral infarction
Rtpa thrombolysis
Interventional therapy
Safety~ Quality of life
