摘要
目的观察芪苓肾消汤治疗气阴两虚夹瘀型糖尿病肾病(DKD)的临床疗效。方法将79例DKD患者随机分为2组。对照组39例在常规西医治疗的基础上给予缬沙坦胶囊口服,治疗组40例在对照组治疗方法的基础上加用芪苓肾消汤治疗。治疗8周后评定疗效,并比较2组的中医证候积分,尿微量白蛋白(MAU)、24小时尿蛋白定量、尿素氮(BUN)、血肌酐(Scr)、内生肌酐清除率(Ccr)、空腹血糖(FBG)及糖化血红蛋白(Hb A1c)含量,不良反应发生情况。结果对照组总有效率为66.7%,治疗组为90.0%,2组比较差异有统计学意义(P<0.05)。2组治疗后中医证候积分均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。2组治疗后MAU、24小时尿蛋白定量及BUN显著降低,Ccr显著升高,与同组治疗前比较,差异均有统计学意义(P<0.05);治疗组治疗后Scr显著降低,与同组治疗前比较,差异有统计学意义(P<0.05);治疗组对各项指标的改善程度明显优于对照组(P<0.05)。2组治疗前后FBG,Hb Alc比较,差异均无统计学意义(P>0.05)。结论芪苓肾消汤可有效改善气阴两虚夹瘀型DKD患者的临床症状及肾功能指标,方法可行,疗效可靠,值得临床推广应用。
Objective To investigate the curative effect of Qiling Shenxiao Tang in treating diabetic kidney disease（ DKD） that deficiency of both qi and yin with blood stasis. Methods 79 DKD patients were randomly d ivided into treatment group（ 40 cases） and control group（ 39 cases）. The control group took Valsartan capsules orally on the basis of conventional western medicine while the treatment group was treated with Qiling Shenxiao Tang addtionally besides Valsartan capsules. After 8 weeks,the curative effect,syndrome integrals,microalbuminuria（ MAU）,24 h quantitation of urine protein（ UP）,blood urea nitrogen（ BUN）,endogenous creatinine clearance rate（ Ccr） and serum creatinine（ Scr）,fasting blood glucose（ FBG）,glycated hemoglobin（ Hb Alc） and adverse effect were detected and analyzed statistically. Results The total effective rate in control group was 6 6.7% while that in treatment group was 90.0%,the difference was statistically significant（ P〈0.05）. Syndrome integrals of two groups decreased evidently after treatment while that of treatment group changed more,the differences were all s ignificant（ P〈0.05）. Indexes of MAU,UP（ 24 h） and BUN decreased while that of Ccr increased in both groups after treatment,there were significant differences（ P 0. 05）. Scr decreased in treatment group more than before while improvement in it was better than that in control group（ P〈0.05）. There were no significant differences in FBG and Hb Alc after treatment（ P〈0.05）. Conclusion Qiling Shenxiao Tang is effective in r elievig syndrome of DKD that deficiency of both qi and yin with blood stasis and improving renal function. The therapy is feasible and realiable,worth popularizing and applying in clinic.
出处
《甘肃中医药大学学报》
2017年第6期48-52,共5页
Journal of Gansu University of Chinese Medicine
基金
江苏省自然科学基金项目(BK20151572)
关键词
糖尿病肾病
气阴两虚夹瘀型
芪苓肾消汤
缬沙坦胶囊
临床观察
diabetic kidney disease
deficiency of both qi and yin with blood stasis
Qiling Shenxiao Tang
Valsartan capsules
clinical observation
