摘要
试验旨在建立鸡生长抑制模型并评价兽用陈皮口服液对鸡生长抑制的治疗效果。选用磺胺间甲氧嘧啶钠、硫酸阿托品和地塞米松磷酸钠3种药物建立鸡生长抑制模型,从中选择一种效果较好的药物进行后续试验。结果显示,在生长抑制模型建立试验中,地塞米松组平均日增重(ADG)最低,显著低于对照组(P<0.05),料重比(F/G)最高,且显著高于对照组(P<0.05),且十二指肠和空肠绒毛高度均显著低于对照组(P<0.05),表明地塞米松组生长抑制效果最好,本试验选用地塞米松磷酸钠给药建立鸡生长抑制模型进行后续试验。在兽用陈皮口服液对鸡生长抑制治疗效果评价试验中,将50只AA肉鸡随机分为5组,每组10只。第1~4组分别胸肌注射地塞米松磷酸钠0.25mg/kg体重,连续给药8d,人工造病形成生长抑制模型;第9天开始,第1~3组连续7d分别灌服0.1、0.2和0.3mL/kg体重的陈皮口服液;第4组为阳性对照组,第9~16天不使用陈皮口服液,灌服等量灭菌生理盐水;第5组为阴性对照组,用等量灭菌生理盐水代替地塞米松磷酸钠,连续注射8d,第9~16天灌服等量灭菌生理盐水。治疗结束时,第2、3组平均日增重高于第4组(阳性对照组),与空白对照组差异不显著(P>0.05),料重比低于第4组,且与空白对照组差异不显著(P>0.05);陈皮口服液治疗组脏器系数及血液生化指标(除谷草转氨酶(AST)外)与空白对照组基本接近(P>0.05),说明陈皮口服液能明显缓解地塞米松对肉仔鸡的生长抑制,修复地塞米松生长抑制肉仔鸡的脏器损伤,且高剂量组(0.3mL/kg体重)缓解作用更好。
In order to determine the clinical efficacy of the oral liquid of dried tangerine peel on chicken growth inhibition,three kinds of methods were used to establish the broiler growth inhibition model（sulfamonomethoxine sodium,atropine sulfate and dexamethasone sodium phosphate）for choosing a best modeling method.The results showed that the ADG of dexamethasone group was lowest which was significantly lower than that of control group（P〈0.05）,and F/G of dexamethasone group was highest which was significantly higher than that of control group（P〈0.05）,indicating that the dexamethasone had the best efficacy to establish the broiler growth inhibition model.At the experiment of effect evaluation dried tangerine peel of the oral liquid on growth suppression of chicken,50 AA broilers were chosen and divided into 5 groups,the broilers in groups 1 to 4 were intramuscular injection 0.25 mg/（kg·BW）dexamethasone sodium phos-phate for 8 dwhile the blank control group was intramuscular injection normal saline.At the 9 th day,the broilers in groups 1,2 and 3 were drenched 0.1,0.2 and 0.3 mL/（kg·BW）for 7 d,the groups 4 and 5 were drenched the normal saline.The results showed that,after treatment,the ADG of groups 2 and 3 were higher and F/G was lower than group 4,while they all had no significant difference with blank control group（P〈0.05）,the organ and blood biochemical indexes（except AST）of groups 1,2 and 3 had no significant difference with blank control group（P〈0.05）,indicating that the oral administration of dried tangerine peel could relieve the growth inhibition and repair the damage of the organ,high dose of dried tangerine peel oral liquid（0.3 mL/（kg·BW））could effectively treat dexamethasone-induced growth inhibition.
出处
《中国畜牧兽医》
CAS
北大核心
2018年第1期249-255,共7页
China Animal Husbandry & Veterinary Medicine
基金
福州市科技项目(榕科[2011]106)
关键词
肉仔鸡
生长抑制模型
陈皮口服液
药效评价
broilers
growth inhibition model
dried tangerine peel oral liquid
efficacy evaluation
