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血清hs-CRP及VEGF水平对急性心肌梗死经皮冠状动脉介入治疗术后心血管事件的影响 被引量:36

Effects of hs-CRP and VEGF on major adverse cardiovascular events in patients with acute myocardial infarction after percutaneous coronary intervention
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摘要 目的探讨血清高敏C反应蛋白(hs-CRP)及血管内皮生长因子(VEGF)对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后主要心血管不良事件(MACE)的影响。方法选择AMI行PCI术后患者116例,根据术后是否发生MACE随机分为MACE组20例,非MACE(NMACE)组96例,分析术前,术后1 h、24 h及7 d血清hsCRP及VEGF水平。结果术后1 h、24 h、7 d,MACE组血清hs-CRP分别为(5.79±1.13)、(6.87±1.42)、(3.51±0.89)mg/L,VEGF分别为(167.8±49.8)、(146.8±43.9)、(121.5±29.6)pg/m L;NMACE组血清hs-CRP分别为(4.57±1.09)、(5.38±1.21)、(2.67±0.58)mg/L,VEGF分别为(145.7±40.3)、(115.6±39.7)、(95.7±21.7)pg/m L,两组不同时间点血清hs-CRP、VEGF比较差异均有统计学意义(P均<0.05)。结论血清hs-CRP及VEGF水平对预测AMI患者PCI术后MACE具有一定的临床价值。 Objective To explore effects of serum high-sensitivity C-reactive protein( hs-CRP) and vascular endothelial growth factor( VEGF) on the major adverse cardiovascular events( MACE) in patients with acute myocardial infarction( AMI) after percutaneous coronary intervention( PCI). Methods Totally 116 patients with AMI were treated by PCI. According to the occurrence of MACE after PCI,the patients were divided into the MACE group of 20 cases and nonMACE( NMACE) group of 96 cases. We analyzed the levels of hs-CRP and VEGF in patients before PCI,and at 1 h,24 h,and 7 d after PCI. Results At 1 h,24 h,and 7 d after PCI,the serum hs-CRP levels were( 5. 79 ± 1. 13),( 6. 87 ±1. 42),and( 3. 51 ± 0. 89) mg/L in the MACE group,and the serum VEGF levels were( 167. 8 ± 49. 8),( 146. 8 ±43. 9),and( 121. 5 ± 29. 6) pg/m L,respectively; the serum levels of hs-CRP in the NMACE group were( 4. 57 ± 1. 09),( 5. 38 ± 1. 21),and( 2. 67 ± 0. 58) mg/L,and the serum hs-CRP levels were( 145. 7 ± 40. 3),( 115. 6 ± 39. 7),and( 95. 7 ± 21. 7) pg/m L,respectively. Significant differences were found at different time points between these two groups( all P〈0. 05). Conclusion The serum hs-CRP and VEGF levels have some clinical value in predicting the occurrence of MACE in patients with AMI after PCI.
作者 艾民 颜昌福 夏福纯 周双陆 贺剑 AI Min;YAN Changfu;XIA Fuchun;ZHOU Shuartglu;HE Jian(Pangang General Hospital of Kunming University of Science and Technology, Panzhihua 617023, China)
出处 《山东医药》 CAS 2018年第1期16-18,共3页 Shandong Medical Journal
基金 四川省医学科研课题(S16046) 四川省卫生和计划生育委员会科研课题(150097)
关键词 急性心肌梗死 经皮冠状动脉介入治疗 C反应蛋白质 血管内皮生长因子 acute myocardial infarction percutaneous coronary intervention high-sensitivity C-reactive protein vascular endothelial growth factor
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  • 1沈桂彬.C-反应蛋白与急性心肌梗死后左心室重塑关系的临床研究[J].黑龙江医学,2013,37(5):324-326. 被引量:1
  • 2彭国顺,林晓虹.辛伐他汀早期应用对急性心肌梗死患者C-反应蛋白及白细胞介素-18的影响[J].中国心血管病研究,2004,2(7):533-534. 被引量:5
  • 3Hansson GK. Immune mechanisms in atherosclerosis [J]. Ar terioscler Thromb Vasc Biol, 2001,21 (12) : 1876-1590.
  • 4Ross R. Ather osclerosis is an inflammatory disease[J]. Am Hear t J, 1999, 138(5 Pt2) :$419-420.
  • 5Lee Y, Lee WH, Lee SC, et al. CD40L activation in circulating platelets in patients with acute coronary syndrome [ J ]. Cardiology, 1999,92 ( 1 ) : 11-16.
  • 6Aukrust P, Muller F, Ueland T, et al. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possi- ble reflection of Tlymphoeyte and platelet involvement in the pathog enesis of acute coronarysyndromes [ J ]. Circulation, 1999, 100 (6) :614-620.
  • 7中华医学会心血管病分会,中华心血管病杂志编辑委员会.不稳定性心绞痛诊断和治疗建议[J].中华心血管病杂志,2000,26(12):409-412.
  • 8Kristinas, Juliapo, Fruchartjc, et al. 3-Hydroxy- 3-methylglut aryl CoA reducetase inhib-itors reduce-rllmtrlg tyceride levels through mod- ulation of apollpoprote in C-III and lipoproteinlipase [ J]. FEBS Lett, 1999,452 : 160-164.
  • 9Ridker PM, Rifai N, Pfeffer MA, et al. Long-term effects of pravasta- tin on plasma concentration o f C-r eactive protein. The Cholesterol and Recur rent Events (CARE) Investigators [ J ]. Circulation, 1999, 100(3) :230-235.
  • 10Syed MA,Borzak S,Asfour A,et al. Single lead ST-segment recovery: a single, reliable measure of successful fibrinolysis after acute myocardial infarction. Am Heart J, 2004,147 : 275 -280.

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