摘要
5-脂氧合酶(5-lipoxygenase,5-LOX)是催化花生四烯酸(arachidonic acid,AA)生成5-羟基-6,8,11,14-二十碳四烯酸(5-hydroperoxy-6,8,11,14-eicosatetraenoic acid,5-HPETE)和各种白三烯(leukotrienes,LTs)类物质的关键酶。近年来研究显示,5-LOX参与阿尔茨海默病(Alzheimer’s disease,AD)的病理生理过程。抑制5-LOX可以降低β淀粉样蛋白(β-amyloid peptide,Aβ)的沉积、tau蛋白磷酸化、减轻神经炎症反应和调节突触功能,改善AD的认知功能障碍。该文就5-LOX与AD相关性研究进展进行综述。
5-1ipoxygenase plays a key role in catalyzing the conversion of arachidonic acid （AA） to 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid （5-HPETE）, which can then be metabolized into different leukotrienes （LTs）. The recently studies have shown that 5-1ipoxygenase is involved in the pathophysiology of Alzheimer＇s disease. Inhibition of 5-1ipoxygenase decreases amyloid ]3 peptide （AI3） and tau hyperphosphorylation,mitigates neuroinflammation,regulates synaptic function and ameliorates cognitive disorders in Alzheimer＇s disease. In this review,we will summarize studies of 5-1ipoxygenase in Alzheimer＇s disease pathogenesis.
作者
杜贯涛
张春腾
洪浩
DU Guan-tao;ZHANG Chun-teng;HONG Hao(Department of Pharmacy,Nanjing Medical University Subsidiary Changzhou No.2 People＇s Hospital Changzhou, 213003, China;Department of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China)
出处
《神经药理学报》
2016年第5期39-44,共6页
Acta Neuropharmacologica
基金
国家自然科学基金面上项目(No.81273497
NO.81573413)
