摘要
细胞焦亡是一种促炎的程序性死亡方式,其表现为炎性小体中的炎性半胱天冬氨酸蛋白酶(Caspases-1,4,5和11)的活化和促炎细胞因子白介素-1β和白介素-18的分泌。最新研究表明GSDMD作为炎性半胱天冬氨酸蛋白酶的下游底物,通过在质膜上打孔来执行细胞焦亡事件的发生。由于细胞焦亡广泛地参与各种疾病的发生和发展,因此更好地了解细胞焦亡的机制将有助于为焦亡相关疾病的治疗提供新的方案和手段。
Pyroptosis is inflammatory programmed cell death,which is characterized by activation of inflammatory caspases（caspases 1,4,5,and 11）in inflammasomes and secretion of inflammatory cytokines such as interleukin-1β and interleukin-18.Recent studies have reported that GSDMD acts as an essential downstream substrate of inflammatory caspases,performing pyroptosis by forming pores in the plasma membrane.Since pyroptosis is widely involved in the onset and development of various diseases,a better understanding of the mechanism of pyroptosis will facilitate new approaches to and methods of treating pyroptosis-related diseases.
作者
陶慧慧
陶欣荣
TAO Hui-hui;TAO Xin-rong(Schoolof Medicine, Anhui University of Science ＆ Technology, Huainan, Anhui 232001, China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2017年第12期1219-1221,共3页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.81471161)
安徽省青年骨干人才国内访学项目(No.gxfxZD2016070)
