摘要
目的:评估益生菌对非酒精性脂肪肝的生化指标及超声分级的影响。方法:回顾性分析64例非酒精性脂肪肝肥胖患者三盲试验。患者随机分为2组,分别服用益生菌制剂或安慰剂,治疗3疗程。结果:益生菌组,谷丙转氨酶平均水平从32.8±19.6U/L下降至23.1±9.5 U/L(P=0.002),天冬氨酸转氨酶平均水平从32.2±15.7U/L下降至24.3±7.7U/L(P=0.002),患者的胆固醇、低密度脂蛋白、甘油三酯以及腰围显著降低,而体重、身体质量指数、体重指数z评分没有显著改变;安慰剂组,研究前后各项指标无显著变化,无统计学差异。肝超声分级,益生菌组转阴17例(53.12%)、安慰剂组转阴5例(15.62%)。结论:益生菌可以有效地改善肥胖儿童非酒精性脂肪肝病症。
Objective To evaluate the effects of some probiotics on biochemical and sonographic of nonalcoholic fatty liver disease( NAFLD). Method This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule or placebo for 12 weeks. Result After intervention,in the probiotic group the mean levels of alanine aminotransferase decreased from 32. 8 ± 19. 6 to 23. 1 ± 9. 5 U/L( P = 0. 002) and mean aspartate aminotransferase decreased from 32. 2 ± 15. 7 to24. 3 ± 7. 7 U/L( P = 0. 002). Likewise the mean cholesterol,low-density lipoprotein-C and triglycerides as well as waist circumference decreased in the intervention group,without significant change in weight,body mass index and body mass index z score. In the placebo group,there was no significant change in the indexes befor and after the study. After the trial,normal liver sonography was reported in 17( 53. 12%)and 5( 15. 62%) of patients in the intervention and placebo groups,respectively. Conclusion The present findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD.
出处
《中国食物与营养》
2018年第1期69-71,79,共4页
Food and Nutrition in China
关键词
青少年
儿童
非酒精性脂肪肝
肥胖
益生菌
adolescent
children
nonalcoholic fatty liver disease(NAFLD)
obesity
probiotics
