摘要
【目的】探讨颈内动脉支架置入术联合药物治疗对重度颈内动脉狭窄患者脑血流灌注参数及认知功能的影响。【方法】选择2014年6月-2016年6月收治的重度颈内动脉狭窄患者124例为研究对象,采用随机数字表法分为治疗组和对照组各62例,对照组单纯药物治疗,治疗组给予颈内动脉支架置术后联合药物治疗。随访1年,比较两组脑血流灌注参数、认知功能、不良事件等指标。【结果】治疗组相对达峰时间(rTTP)、相对平均通过时间(rMTT)、相对脑血容量(rCBV)、相对脑血流量(rCBF)均明显低于对照组(P<0.05,P<0.01);简易精神状态检查表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分明显高于对照组(P<0.05);血管闭塞、血管再狭窄、新发脑梗塞、短暂性脑缺血明显低于对照组(1.61%vs 11.29%,4.84%vs 19.35%,1.61%vs 14.52%,4.84%vs 17.74,P<0.05)。【结论】颈内动脉支架置入术联合药物治疗有助于改善重度颈内动脉狭窄患者脑血流灌,提高认知功能,预防不良事件发生。
【objective】To study effect of cerebral blood perfusion and cognitive function of carotid artery stenting com-bined with medical therapy for patients with severe internal carotid stenosis.【Methods】124 patients with severe internal ca-rotid stenosis from June 2014 to June 2016 were divided into observed group and the treatment group,The treatment groupgiven pure medical therapy,observation group given carotid artery stenting combined with medical therapy. One year follow-upr,cerebral blood flow perfusion,cognitive function,adverse events were compared between two groups.【Result】The ob-servation group rTTP,rMTT,rCBV,rCBF were significantly lower than treatment group(P<0.05,P<0.01);MMSE,MoCA score were significantly higher than treatment group(P<0.05);Vascular Occlusion,vascular restenosis,cerebral ischemicstroke,transient cerebral ischemia were significantly lower than treatment group(1.61% vs 11.29%,4.84% vs 19.35%,1.61% vs 14.52%,4.84% vs 17.74,P<0.05).【Conclusion】Carotid artery stenting combined with medical therapy help toimprove cerebral blood flow perfusion in patients with severe internal carotid stenosi,improve cognitive function,and pre-vent adverse events.
出处
《中山大学学报（医学版）》
CAS
CSCD
北大核心
2018年第1期107-112,共6页
Journal of Sun Yat-Sen University:Medical Sciences
基金
海南省卫生计生行业科研项目(1601032054A2001)
关键词
重度颈内动脉狭窄
颈内动脉支架置入
药物治疗
脑血流灌注
认知功能
severe internal carotid stenosis
carotid artery stenting
medical therapy
cerebral blood flow perfusion
cognitive function
