摘要
目的:观察太芪培元颗粒治疗气阴两虚肺肾不足的人类免疫缺陷病毒(HIV)感染者的临床疗效。方法:采取前瞻性队列研究的方法,纳入HIV感染者81例,给予太芪培元颗粒口服180d,按照CD4+T淋巴细胞计数上升>50个和上升<5个分为治疗有效组和治疗无效组,并按照性别、民族匹配选取10个样本进行病例观察。观察指标包括CD4+T淋巴细胞、CD8+T淋巴细胞、中医症状体征积分、HIV-RNA病毒载量的差异。结果:治疗有效组CD4+T淋巴细胞显著升高(P<0.05),中医症状体征总积分显著降低(P<0.05),治疗无效组CD4+T淋巴细胞显著降低(P<0.05)。且总样本前后比较,中医症状体征总积分降低,差异有统计学意义(P<0.05);对CD4+T淋巴细胞和中医症状总积分进行Pearson相关分析得出,治疗有效组、治疗无效组以及总样本中这种相关性均无统计学意义。结论:太芪培元颗粒可有效改善气阴两虚肺肾不足型HIV感染者中医症状总积分,且这种改善与CD4+T淋巴细胞计数的升高不具有相关性。
Objective: To observe the clinical curative effect of the HIV-infected patients who were deficiency of both qi-yin and lungkidney by taking taiqipeiyuan granules. Methods: A prospective cohort study were conducted in 81 cases of HIV-infected patients,and oral administration of taiqipeiyuan granules were given for 180 d. CD4+T lymphocyte count increased > 50 and ascending < 5 were grouped condition for the effective treatment group and ineffective treatment group,and 10 samples were selected according to gender and ethnic match for case observation. Observations included CD4+T lymphocytes,CD8+T lymphocytes,TCM symptom integrals,HIV-RNA virus load. Results: In the effective treatment group the increase of CD4+T lymphocytes and the decrease of TCM syndrome integrals were significant( P < 0. 05),and the CD4+T lymphocytes in the ineffective treatment group were significantly decreased( P < 0. 05). Compared with the total sample before and after treatment,the decrease of TCM symptom integration was significant( P < 0. 05). According to Pearson correlation analysis of CD4+T lymphocyte and TCM symptom integrals,this correlation was not statistically significant in the effective treatment group,the ineffective treatment group and the total sample. Conclusion: Taiqipeiyuan granules can effectively improve the integration of TCM symptoms in patients who was deficiency of both qi-yin and lung-kidney,and this improvement has no correlation with the increase of CD4+T lymphocyte count.
出处
《中国医药导刊》
2017年第12期1378-1381,共4页
Chinese Journal of Medicinal Guide
基金
国家"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项(项目编号:2014ZX10005003
项目名称:中西医结合治疗艾滋病应用技术研究)
中医药防治重大疑难疾病临床服务能力建设项目(项目编号:201405
项目名称:太芪培元颗粒对艾滋病患者差异蛋白的研究)
