摘要
目的探讨孕中晚期低甲状腺素血症孕妇在补碘和非补碘的情况下甲状腺功能的变化。方法按照随机数字表法将福建医科大学附属龙岩第一医院内分泌科2016年1月~2017年7月100例孕中晚期低甲状腺素血症孕妇分组。对照组给予优甲乐治疗,观察组则在对照组基础上通过补充食物碘进行干预或联合含碘孕妇复合维生素进行口服(每一粒有150μg碘)。比较两组疾病干预总有效率;孕产妇、围产儿不良结局出现率;干预前后患者甲状腺功能指标TSH、FT3、FT4监测水平。结果观察组疾病干预总有效率高于对照组,P<0.05;观察组孕产妇、围产儿不良结局出现率少于对照组,P<0.05;干预前两组甲状腺功能不同指标监测水平相近,P>0.05;干预后观察组甲状腺功能不同指标监测水平优于对照组,P<0.05。结论食物、含碘孕妇复合维生素联合补碘对孕中晚期低甲状腺素血症孕妇甲状腺功能有明显的改善作用,可改善妊娠结局,减少母婴不良现象的发生,值得推广应用。
Objective To investigate the changes of thyroid function in late pregnant hypothyroxinemic of pregnant women under the condition of iodine and non iodine. Methods From January 2016 to July 2017, according to the random number table method, 100 pregnant women with low thyroxine levels in the endocrine department of Longyan First Hospital Affiliated to Fujian Medical University were grouped. The patients of control group were treated with euthyrox, the patients of observation group on the basis of the control group were supplementing with food iodine or orally administered combining iodine-containing pregnant women with multivitamins（150 μg of iodine per tablet）. The total effective rate of intervention, the incidence of adverse outcomes in maternal and perinatal children, the levels of thyroid function indicators TSH, FT3 and FT4 in the two groups were monitored and compared before and after intervention. Results The total effective rate of disease intervention in observation group was higher than that in control group（P 〈0.05）. The incidence of adverse outcomes in maternal and perinatal children in observation group was less than that in control group（P 〈0.05）. The monitoring levels of different indexes of thyroid function in the two groups were similar before intervention（P 〉0.05）. After intervention, the monitoring levels of different indexes of thyroid function in observation group were better than those in control group（P 〈0.05）. Conclusion Food, vitamin supplementation combined with iodine of pregnant women has obvious effect on improving the thyroid function in late pregnant hypothyroxinemic of pregnant women,which can improve the pregnancy outcome and reduce the maternal and infant adverse phenomena, which is worth popularizing and applying.
出处
《中国医药科学》
2017年第24期90-92,126,共4页
China Medicine And Pharmacy
关键词
补碘
孕中晚期低甲状腺素血症
孕妇甲状腺功能
妊娠结局
Iodine supplementation
Late pregnancy hypothyroxinemia
Thyroid function of pregnant women
Pregnancy outcome
