摘要
目的探讨老年男性服用钙和维生素D复方制剂(以下简称复方钙剂)与骨密度、骨代谢标志物(BMMs)的关系。方法对505例老年男性服用复方钙剂的情况进行调查,根据服用复方钙剂情况分为服用组87例和未服用组418例,比较两组老年男性骨密度和BMMs水平的差异,并进一步比较服用复方钙剂不同时间段(7~24个月、25~60个月和61个月以上)老年男性的BMMs水平。结果服用组骨质正常率为46.0%,明显高于未服用组的34.7%,差异有统计学意义(P<0.05)。与未服用组相比,服用组血清I型胶原羧基端肽β特殊序列(CTX)和甲状旁腺素(PTH)水平较低、25-羟基维生素D[25(OH)D)]水平较高,差异均有统计学意义(均P<0.01)。服用复方钙剂不同时间段患者之间CTX、PTH和25(OH)D水平比较差异均有统计学意义(均P<0.05)。结论老年男性长期服用复方钙剂有助于降低其血清CTX和PTH水平,提高其血清25(OH)D水平,进而提高其骨质正常率。
Objective To investigate the relationship between supplement of calcium carbonate and vitamin D compound（calcium compound）, and bone mineral density （BMD） and bone metabolism markers （BMMs） in elderly men. Methods A totalof 505 male subjects aged 65-98 years were enrolled in the study, including 87 cases taking calcium compound in the past6months （study group） and 418 cases not taking calcium compound （control group）. The levels of BMD and BMMs were detectedand compared between two groups; and also compared in study group at different time points （7-24m, 25-60m and 61m-）.Results Normal bone mass was found in 46.0% in study group, which was significantly higher than that in control group （34.7%,P〈0.05）. The levels of C-telopeptide of type 1 collagen（CTX） and parathyroid hormone（PTH） were significantly lower, and serum25-hydroxyvitaminD [25（OH）D] was significantly higher in study group than those in control group（all P〈0.01）. The differencesof CTX, PTH and 25（OH）D between two groups at all time points were statistically significant （all P〈0.05）. Conclusion To supplycalcium compound can decrease the level of CTX and PTH, and increase 25（OH） D level and the normal bone mass.
出处
《浙江医学》
CAS
2018年第2期145-147,151,共4页
Zhejiang Medical Journal
基金
浙江省医药卫生科技计划项目(2016ZDA002
2018KY222)
关键词
骨质疏松
碳酸钙
维生素D
骨密度
骨代谢标志物
老年男性
Osteoporosis Calcium carbonate VitaminD Bone mineral density Bone metabolism markers Elderlymen
