摘要
目的探析他汀类药物对老年脑动脉狭窄患者炎性因子表达的影响。方法以本院2013年3月至2015年3月期间收治的75例老年脑动脉狭窄患者作为研究对象，随机分为观察组（n=38）与对照组（n=37）。两组均于术前5d开始应用抗血小板药物，观察组在此基础上加用阿托伐他汀钙片，比较两组术后不良事件发生率及治疗前后血浆超敏C反应蛋白（hs—CRP）与血清白细胞介素-6（IL-6）等炎性因子水平。结果观察组与对照组术后不良事件发生率分别为2．6％、10．8％，差异无统计学意义（P〉0．05）。两组治疗前hs—CRP与IL-6比较差异均无统计学意义（均P〉0．05）；治疗后观察组hs—CRP与IL-6均低于对照组，差异均有统计学意义（均P〈0．05）。结论他汀类药物在老年脑动脉狭窄患者中的应用可有效减轻血管内皮炎症损伤、抑制炎性因子表达，效果显著。
Objective To explore the effect of statins on the expression of inflammatory factors in elderly patients with cerebral arterial stenosis. Methods 75 elderly patients with cerebral arterial stenosis treated in our hospital from March 2013 to March 2015 were selected as the object of study, were randomly divided into the observation group （n=38） and the control group （n=37）. Both groups received anti-platelet drugs 5 days before the surgery, and the observation group was treated with atorvastatin calcium on the basis. The incidence of adverse events and inflammatory factors （plasma hs-CRP and serum IL-6） levels before and after the treatment were compared. Results The incidence of adverse events was 2.6% in the observation group and 10.8% in the control group, without statistically significant difference （P〉0.05）. There were n~ statistically significant differences in the levels of hs-CRP and IL-6 between the two groups before the treatment （P〉0.05）; after the treatment, the levels of -hs-CRP and IL-6 in the observation group were lower than those in the control group, with statistically significant differences （P〈0.05）. Conclusion The application of statins in elderly patients with cerebral arterial stenosis can significantly reduce the vascular endothelial inflammatory injury, and inhibit the expression of inflammatory factors.
出处
《国际医药卫生导报》
2018年第3期392-394,共3页
International Medicine and Health Guidance News
关键词
脑动脉狭窄
他汀类药物
炎性因子
血管内皮
Cerebral arterial stenosis
Statins
Inflammatory cytokines
Vascular endothelium
