摘要
目的研究黛力新联合替普瑞酮对慢性胃炎患者临床疗效及其焦虑抑郁情绪的影响。方法选取我院2014年7月~2016年6月间收治的慢性胃炎患者136例,采用随机数字法将其分为对照组和观察组,每组各68例,对照组患者采用替普瑞酮治疗,观察组采用黛力新联合替普瑞酮治疗。比较两组患者临床疗效及治疗后不良反应情况,同时比较治疗前后两组患者汉密尔顿抑郁量表(HAMD)评分及汉密尔顿焦虑量表(HAMA)评分。结果治疗后,观察组患者HAMD评分及HAMA评分均明显低于对照组(t=-2.258、-3.029,P<0.05);治疗后观察组患者临床总有效率(86.76%)明显高于对照组(70.59%)(χ~2=5.303,P<0.05);治疗前患者HAMD评分、HAMA评分及治疗后不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论黛力新联合替普瑞酮治疗慢性胃炎患者,可以明显缓解患者焦虑抑郁情绪,提高临床治疗效果,改善患者生活质量,同时治疗后不良反应较少,值得在临床推广应用。
Objective To study the effect of Deanxit combined with teprenone on the clinical efficacy and anxiety and depression in the patients with chronic gastritis. Methods 136 patients with chronic gastritis who were admitted to our hospital from July 2014 to June 2016 were selected as the study subjects. Random number method was used to divide them into control group and observation group, with 68 cases in each group. The control group was given teprenone, and the observation group was given Deanxit combined with teprenone. The clinical efficacy and adverse reactions of the two groups were compared. The Hamilton Depression Rating Scale（HAMD） scores and Hamilton Anxiety Scale （HAMA） scores were compared between the two groups before and after treatment. Results After treatment, HAMD scores and HAMA scores in the observation group were significantly lower than those in the control group （t=-2.258, -3.029, P〈0.05）; after treatment, the total clinical effective rate（86.76%） in the observation group was significantly higher than that in the control group （70.59%）（X^2=5.303, P〈0.05）; before treatment, the HAMD score, HAMA score and the in- cidence of adverse reactions after treatment were compared with those in the control group, and the differences were not statistically significant （P〉0.05）. Conclusion Oeanxit combined with teprenone in the patients with chronic gastritis can significantly relieve the anxiety and depression in patients, improve clinical efficacy, improve quality of life, while the adverse reactions are fewer after treatment, which is worthy of clinical promotion and application.
出处
《中国现代医生》
2018年第2期92-95,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2017KY598)
