摘要
目的比较鼻式持续气道正压通气（NCPAP）和鼻式双水平正压通气（nBiPAP）对于预防超低出生体重早产儿拔管失败的效果差异。方法选取本院80例收入NICU、体重〈1000g的早产儿作为研究对象，均采取无创辅助呼吸，根据通气方式差异分成NCPAP组和nBiPAP组，比较初次拔管失败率、拔管前后血气指标变化及各种并发症发生率。结果nBiPAP组初次拔管失败率为7．5％，明显低于NCPAP组的35．0％（P〈0．05）。nBiPAP组拔管后2h、12hnBiPAP组的PaO2水平均高于同期的NCPAP组，PaCO2水平低于同期的NCPAP组（均P〈0．05）。两组鼻黏膜损伤、呼吸暂停等并发症发生率比较差异无统计学意义（P〉0．05）。结论nBiPAP作为预防超低出生体重早产儿拔管失败的效果要优于NCPAP，但安全性方面还需要大样本长期研究。
Objective To explore the effects of nasal continuous positive airway pressure （NCPAP） versus nasal double level positive pressure ventilation （nI3iPAP） in the prevention of extubation failure in premature infants with ultra low birth weight. Methods Eighty preterm infants weighing less than 1 000 g and admitted into the NICU of our hospital were selected as study objects. All the objects took non-invasive breathing. The objects were divided into an NCPAP group and an nBiPAP group according to the different ventilations. The first extubation failure rate, the blood gas indicators before and after the extubation, and the incidence of comlications were compared between these two groups. Results The first extubation failure rate was 7.5% in the nBiPAP group and 35.0% in the NCPAP group （P〈0.05）. 2 and 12 h after the extubation, the PaO2 levels were higher and the PaCO2 levels were lower in the nBiPAP group than in the NCPAP group （P〈0.05）. There was no statistical difference in the incidence of complications such as nasal mucosa injury, apnea, and so on between these two groups （P〉0.05）. Conclusion nBiPAP in the prevention of extubation failure in ultra-low birth weight premature children is better than NCPAP, but the safety aspect needs a large-scale long-term study.
出处
《国际医药卫生导报》
2018年第4期508-511,共4页
International Medicine and Health Guidance News
关键词
鼻式持续气道正压通气
鼻式双水平正压通气
超低出生体重早产儿
拔管失败
Nasal continuous positive airway pressure
Nasal double level positive pressure ventilation
Ultra low birth weight premature children
Extubation failure
