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幽门螺杆菌感染与老年早期胃癌病程及IL-6、TGF-β1、TNF-α因子的相关性 被引量:17

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摘要 目的探讨幽门螺杆菌(Hp)感染与老年早期胃癌患者的病程及胃癌相关细胞因子白细胞介素(IL)-6、转化生长因子(TGF)-β1和肿瘤坏死因子(TNF)-α释放的关系。方法收集胃癌患者59例,均接受^(13)C呼气法检测Hp感染情况,依据Hp感染情况分为阳性与阴性两组,分析Hp感染对两组胃癌病程变化及胃癌相关细胞因子IL-6、TGF-β1、TNF-α的影响。结果 Hp感染以男性患者居多(t=4.32,P<0.05),Hp感染对胃癌分期的影响差异有统计学意义(t=5.77,P<0.05),感染阳性者凹陷型病例居多,Hp感染对老年早期胃癌的病理分型无明显影响(P>0.05),Hp阳性感染患者IL-6(t=6.15,P<0.05)及TGF-β1(t=8.27,P<0.05)均高于阴性组患者。结论老年早期胃癌患者应尽早接受Hp筛查,Hp感染对胃癌病程有影响,阳性感染者应尽早接受抑菌治疗,以有效排除其对胃癌病程的影响。
出处 《中国老年学杂志》 CAS 北大核心 2018年第3期585-586,共2页 Chinese Journal of Gerontology
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