摘要
细胞焦亡是调控性促炎形式引起的细胞死亡,并依赖于属于半胱氨酸依赖性天冬氨酸特异性蛋白酶家族（Caspase）的炎性蛋白酶的酶活性激活。其特征在于孔道的形成,质膜破裂,细胞内容物和促炎症介质进入细胞间质,导致炎症和细胞死亡。其中,炎性小体激活Caspase-1对于细胞焦亡的诱导有着重要的作用。近期的研究表明细胞焦亡在动脉粥样硬化斑块的形成过程中有着重要的作用。本文主要介绍细胞焦亡及其产生机制、巨噬细胞焦亡和内皮细胞焦亡的最新进展,以及细胞焦亡与动脉粥样硬化的关系。
Pyroptosis is a pro-inflammatory form of death, which depends on the enzymatic activation of inflammatory proteases that belong to the family of cysteine-dependent aspartate-specific protease （Caspases）. It is characterized by pore formation, plasma membrane rupture, cellular contents and pro-inflammatory mediators entering extracellular space, leading to inflammation and cell death. The inflammasome-activated Caspase-1 plays an important role in the induction of pyroptosis. Recent reports showed that pyroptosis plays an important role in atherosclerosis. This review article describes the pyroptosis and its mechanism, the progresses of study on the pyroptosis of macrophage and endothelial cell, and the relationship between pyroptosis and atherosclerosis.
作者
李秀珍
黄孝天
符民桂
LI Xiu-Zhen;HUANG Xiao-Tian;FU Min-Gui(School of Basic Medicine, Nanchang University, Nanchang 332330, Jiangxi, China;School of Medicine, University of Missouri Kansas City, Kansas City 64108, USA)
出处
《中国动脉硬化杂志》
CAS
2018年第1期1-6,共6页
Chinese Journal of Arteriosclerosis
基金
美国心脏协会基金资助(17AIREA33660073)
