摘要
目的探讨2型糖尿病(T2DM)患者血清铁蛋白(SF)、同型半胱氨酸(Hcy)、空腹生长抑素(FSS)、胰岛素样生长因子-1(IGF-1)与外周动脉病变(PAD)的关系。方法选取北京天坛医院内分泌科2014年6月至2016年10月收治的160例确诊T2DM患者进行研究,根据踝臂指数(ABI)分组:ABI范围1.0~1.4的患者124例(非PAD组)、ABI范围<1.0的患者46例(PAD组),比较两组患者的血清SF、Hcy、FSS、IGF-1等指标。结果 PAD组患者的年龄、性别、病程、体重指数(BMI)、吸烟率、空腹血糖(FBG)水平与非PAD组比较,差异局均无统计学意义(P>0.05);PAD组患者的收缩压、舒张压、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平与非PAD组比较,差异均有统计学意义(P<0.05);PAD组患者的血清SF、FSS、IGF-1水平与非PAD组比较,差异均有统计学意义(P<0.05);PAD组的Hcy水平与非PAD组比较,差异局均无统计学意义(P>0.05)。采用多元Logistic回归分析结果显示:收缩压、舒张压、HbA1c、HDL-C、SF、IGF-1增高是T2DM患者并发PDA的独立危险因素(P<0.05),FSS、HDL-C水平升高是T2DM患者并发PDA的保护因素(P<0.05)。结论 PAD患者与健康人收缩压、舒张压、HbA1c、TC、TG、HDL-C、LDL-C水平有显著差异,SF、IGF-1、HbA1c、FSS水平升高提示PAD在发生发展。
Objective To study the relationship of serum ferritin（SF）, homocysteine（Hcy）, fasting plasma somatostatin（FSS）, insulin-like growth factor-1（IGF-1） with peripheral arterial disease（PAD） in type 2 diabetes mellitus（T2DM） patients. Methods A total of 160 T2DM patients in our hospital from June 2014 to October 2016 were selected and assigned into two groups according to the ankle brachial index（ABI）： non-PAD group（ABI range of 1 to 1.4, 124 patients）, PAD group（ABI1.0, 46 patients）. The levels of SF, Hcy, FSS, and IGF-1 were compared between the two groups. Results PAD group and non-PAD group showed no statistically significant difference in age and sex, course of disease, BMI, smoking rate, the level of FBG（P0.05）, but they showed statistically significant difference in systolic and diastolic blood pressure, HbA1c, TC, TG, HDL-C and LDL-C levels（P0.05）. Levels of SF, FSS and IGF-1 in PAD group were significantly higher than those in non-PAD group（P0.05）, but the level of Hcy were not significantly different between the two groups（P0.05）. Multivariate logistic regression analysis showed that increased systolic blood pressure, diastolic blood pressure, HbA1c, HDL-C, SF and IGF-1 were independent risk factors of PDA in patients with T2DM（P0.05）, and elevated FSS and HDL-C levels were the protective factors of PDA in patients with T2DM（P0.05）. Conclusion Serum levels of SF, FSS, IGF-1 have a certain relationship with PAD in T2DM patients.
出处
《海南医学》
CAS
2018年第2期187-189,共3页
Hainan Medical Journal
关键词
2型糖尿病
血清铁蛋白
同型半胱氨酸
空腹生长抑素
胰岛素样生长因子-1
外周动脉病变
Type 2 diabetes mellitus
Serum ferritin （SF）
Fasting plasma somatostatin （FSS）
Homocysteine（Hcy）
Insulin-like growth factor-1 （IGF-1）
Peripheral arterial disease （PAD）
