摘要
目的比较抗甲状腺药物(ATD)与甲状腺功能亢进症所致肝功能异常的临床特点。方法回顾性分析43例甲状腺功能亢进症合并肝功能异常患者,将其分为对照组(甲状腺功能亢进症性肝损害)24例和试验组(ATD致肝损害)19例。比较2组患者的肝损害临床表现、肝功能、甲状腺激素水平、治疗及转归等指标。结果试验组和对照组出现肝损害临床表现分别为10.53%(2例/19例)和16.67%(4例/24例),差异无统计学意义(P>0.05)。试验组和对照组的谷丙转氨酶(ALT)升高比例分别为94.74%和100.00%,谷草转氨酶(AST)升高比例分别为94.74%和91.67%。试验组和对照组的血清ALT分别为121.00和89.00 U·L^(-1),AST分别为78.00和60.50 U·L^(-1),差异均有统计学意义(均P<0.05)。结论甲状腺功能亢进症致肝损害和ATD致肝损害患者多数无明显症状,诊断依赖于肝功能监测,ALT和AST是敏感指标,甲状腺功能亢进症致肝损害比ATD致肝损害生化异常更轻。
Objective To compare the clinical features of hyperthyroidism-induced liver dysfunction patients and anti-thyroid drug（ ATD）-induced liver dysfunction patients. Methods Clinical data of 43 liver dysfunction patients with hyperthyroidism was retrospectively analyzed.They were divided into control group（ hyperthyroidism-induced liver injury group,n = 24 cases） and treatment group（ ATD-induced liver injury group,n = 19 cases）. Patients ＇ clinical manifestations,liver function,thyroid hormone level,treatment and outcomes were analyzed.Results There were 10. 53%（ 2 cases/19 cases） and 16. 67%（ 4 cases/24 cases） patients respectively who had liver dysfunction symptoms or signs in treatment group and control group,and there was no statistically significant different（ P 〉0. 05）. Elevated alanine aminotransferase（ ALT） were 94. 74% and 100. 00% in treatment group and control group,and elevated aspartate transaminase（ AST） were 94. 74% and 91. 67%,respectively. In treatment group and control group,serum ALT level were121. 00 and 89. 00 U·L^（-1）,respectively,AST level were 78. 00 and60. 50 U·L^（-1）,respectively,the differences were statistically significant（ all P〈 0. 05）. Conclusion Most liver injury patients with hyperthyroidism didn＇t have liver dysfunction symptoms or signs,so identificationneeded liver function screening. Serum ALT and AST were the sensitive tests in liver function screening. Hyperthyroidism-induced liver dysfunction was milder than that induced by ATD.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第3期244-247,共4页
The Chinese Journal of Clinical Pharmacology
