摘要
目的:探讨人表皮生长因子受体2(humman epidermal growth factor receptor 2,HER2)阳性乳腺癌组织中主要组织相容性复合体-Ⅰ类链相关蛋白A和B(MHC class Ⅰ chain-related protein A/B,MICA/B)的表达水平与患者无病生存期(disease-free survival,DFS)的关系。方法:收集南方医科大学郑州人民医院2009年1月至2010年6月HER2阳性乳腺癌癌旁组织存档蜡块26例及乳腺癌蜡块100例,免疫组化染色检测癌旁组织及癌组织MICA/B的表达水平,采用Kaplan-Meier生存曲线分析其与患者临床病理特征和DFS的关系。结果:MICA/B在癌旁组织中呈阴性(0/26);乳腺癌组织中MICA/B表达率为92%(92/100),其中高表达为65%(65/100);MICA/B在Ⅰ期的高表达率高于Ⅱ~Ⅲ期(77.55%vs 52.94%,P<0.05),在T1期的高表达率高于T2~T4期(75.00%vs 52.27%,P<0.05);ER、PR阳性(阳性细胞数≥1%)组MICA/B高表达率显著低于ER、PR阴性组(ER:52.38%vs74.14%;PR:51.35%vs 73.02%,均P<0.05)。MICA/B的表达与患者的临床分期、ER、PR的表达及肿瘤大小有关(均P<0.05),与绝经状态、组织学分级及淋巴结转移无关(均P>0.05)。无论靶向治疗组(90.6%vs 72.2%,P<0.05)或非靶向治疗组(78.4%vs58.8%,P<0.05)MICA/B高表达组6年DFS均显著高于低表达组。结论:HER2阳性乳腺癌组织中MICA/B高表达与患者的DFS密切相关,可作为患者预后的潜在预测指标。
Objective： To investigate the relationship between expression of MICA/B（MHC class Ⅰ chain-related protein A/B） and disease-free survival（DFS） of patients with HER2^＋（human epidermal growth factor receptor 2） breast cancer tissue. Methods： Twenty six cases of corresponding para-cancerous tissue and 100 cases of HER2^＋breast cancer tissue that preserved in wax at Zhengzhou People＇s Hospital Affiliated to Southern Medical University from January 2009 to June 2010 were collected for this study. Expression of MICA/B in these tissue samples was detected by immunohistochemistry; and the relationship between MICA/B expression with clinicopathologic features as well as DFS was analyzed with Kaplan-Meier survival curve. Results： The expression of MICA/B in adjacent paracancerous tissues was negative（0/26）, however, it was highly positive in cancer tissues（92/100）, and the percentage with high expression was 65%（65/100）, the difference was significant（P〈0.05）. High MICA/B expression rate in stage I was significantly higher than that in stage Ⅱ-Ⅲ（77.55% vs 52.94%,P〈0.05）, and the high expression rate in stage T1 was also significantly higher than that in stage T2-T4（75.00% vs 52.27%,P〈0.05）. High MICA/B expression rate in ER～＋, PR～＋group（with positive number ≥1%） was significantly lower than that in ER-, PR-group（ER：52.38% vs 74.14%,PR：51.35% vs 73.02%,all P〈0.05）. MICA/B expression was correlated with clinical stages, the expression of ER, PR and tumor size（all P〈0.05）, but not associated with menopausal status, histological grade and lymph node metastasis（all P〈0.05）. Over-expression of MICA/B was closely associated with much better 6-year DFS rate in patients no matter with or without targeted therapy（the targeted group： 90.6% vs 72.2%; the untargeted group： 78.4% vs 58.8%, all P〈0.05）. Conclusion： Over-expression of MICA/B in HER2^＋breast cancer tissue is closely related to DFS, which may be served as a potential prognosis indicator for patients with HER2^＋breast cancer.
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
北大核心
2018年第2期177-181,共5页
Chinese Journal of Cancer Biotherapy
基金
郑州市科技局普通资助项目(郑科技[2014]2号)~~
关键词
MHC
Ⅰ类链相关蛋白A/B
人表皮生长因子受体2
乳腺癌
无病生存期
MHC class I chain-related protein A/B（MICA/B）
human epidermal growth factor receptor 2 （HER2）
breast cancer
disease-free survival （DFS）
