摘要
目的观察自制的复方钩藤胶囊对肝阳上亢型高血压的临床治疗效果。方法选取2015-12至2017-02长春中医药大学附属医院收治的肝阳上亢型高血压患者166例,按照随机数字表法将其分为对照组(n=83)和观察组(n=83)。对照组给予硝苯地平缓释片治疗,观察组给予临床自制的复方钩藤胶囊治疗。比较两组在治疗前及治疗30 d后的收缩压、舒张压水平变化及临床治疗效果。结果 (1)治疗30 d后,两组的收缩压、舒张压与治疗前相比均有所降低,差异均有统计学意义(P<0.05);且观察组的收缩压、舒张压改善效果显著优于对照组,差异具有统计学意义(t=22.108,P<0.001;t=12.109,P<0.001)。(2)观察组治疗效果优于对照组,且差异有统计学意义(Z=-3.078,P=0.002);进一步比较,观察组总有效率为92.77%,明显高于对照组的71.08%,差异有统计学意义(χ~2=13.182,P<0.001)。结论对于肝阳上亢型高血压,复方钩藤胶囊降压效果明显,具有很好的临床应用价值。
Objective The objective of this study was to observe the therapeutic effect of self-made compound Uncaria capsule on hypertension of liver-yang hyperactivity. Methods A total sample of 166 liver-yang hyperactivity hypertensive patients, treated in Affiliated Hospital of Changchun University of Traditional Chinese Medicine between December 2015 and February 2017 were selected, and divided into the control group（n=83） and the observation group（n=83） by using the random number table method. The control group was treated with nifedipine sustained-release tablet, and the observation group was provided with self-made compound Uncaria capsule. The changes in systolic and diastolic blood pressure, clinical effect before treatment and 30 days following treatment were compared between the two groups. Results（1） Following 30 days treatment, the systolic blood pressure and diastolic blood pressure of the two groups were decreased compared with those before treatment, the differences were statistically significant（P〈0.05）; and the systolic blood pressure and diastolic blood pressure in the observation group were decreased more significantly than those in the control group（t=22.108,P〈0.001;t=12.109,P〈0.001）.（2） The clinical effect in the observation group was better than the control group, and the difference was statistically significant（Z=-3.078,P=0.002）; further comparison showed that the total efficiency of the observation group（92.77%） was higher than in the control group（71.08%）, the difference was statistically significant（χ~2=13.182,P〈0.001）. Conclusions For liver-yang hyperactivity hypertensive patients, the antihypertensive effect of compound Uncaria is significant, and is worthy of clinical application.
出处
《中华灾害救援医学》
2018年第2期87-90,共4页
Chinese Journal of Disaster Medicine
关键词
复方钩藤胶囊
高血压
肝阳上亢型
compound Uncaria capsule
hypertension
liver-yang hyperactivity
