摘要
目的探究老年手术患者使用盐酸纳布啡注射液进行超前镇痛对血清IL-6、IL-10、TNF-α水平的影响。方法择取2015年12月—2016年12月收治的80例老年手术患者,以随机数字表法将其分为两组,并采用不同超前镇痛方法,研究组(40例)在全麻诱导前采用盐酸纳布啡,对照组(40例)使用同体积生理盐水。对比两组患者术前、术后IL-6、IL-10、TNF-α三项指标上发生的变化。结果术前两组患者的IL-6、IL-10、TNF-α水平相近,差异无统计学意义(P>0.05);术后,两组患者的这三项指标均有所提高,但研究组IL-6、TNF-α低于对照组,IL-10高于对照组,差异有统计学意义(P<0.05)。结论在老年手术患者的全麻诱导前使用盐酸纳布啡进行超前镇痛有助于抑制炎症反应。
Objective To explore the elderly patients using nalbuphine hydrochloride injection effect of preemptive analgesia on serum IL-6, IL-10, TNF-α. Methods 80 elderly patients from December 2015 to December 2016 were selected, they were randomly divided into two groups, and using different methods of analgesia, the study group （40 cases） used induction of general anesthesia before the nalbuphine hydrochloride, the control group （40 cases） used same volume of physiological saline. The changes of three indexes of IL-6, IL-10 and TNF-α were compared between the two groups before and after operation. Results The levels of IL-6, IL-10 and TNF- α were similar in the two groups before operation, and the difference was not statistically signifcant （P 〉 0.05）. After the operation, the three indicators of the two groups were all improved, but the IL-6 and TNF-α in the study group were lower than those in the control group, IL-10 was higher than that in the control group, the difference was statistically signifcant （P 〈 0.05）. Conclusion The use of preemptive analgesic nalbuphine hydrochloride in elderly surgical patients before general anesthesia induction to helps suppress the infammatory response.
作者
蒋琦
JIANG Qi(Department of Anesthesiology, Xiangyang First People＇s Hospital Affliated to Hubei Medical College, Xiangyang Hubei 441000, China)
出处
《中国继续医学教育》
2018年第4期48-50,共3页
China Continuing Medical Education
关键词
盐酸纳布啡
超前镇痛
炎性细胞因子
影响
老年手术患者
nalbuphine hydrochloride
preemptive analgesia
infammatory cytokines
effect
elderly patients
