摘要
目的:探讨神经元特异性烯醇化酶(neuronspecific enolase,NSE)、细胞角蛋白片段19(Cy-fra21-1)、糖类癌抗原199(carcinoma antigen,CA199)、糖类癌抗原125(carcinoma antigen,CA125)、癌胚抗原(carcino-embryonic antigen,CEA)联合检测在肺癌诊断中的应用价值。方法:回顾性分析2015年1月至2017年1月80例肺癌患者的临床资料(观察组),选取同期80例肺部良性病变患者(对照组),两组患者均行血清NSE、Cy-fra21-1、CA199、CA125、CEA检测。结果:观察组患者NSE、Cy-fra21-1、CA199、CA125及CEA均高于对照组(P<0.05);腺癌CA125的阳性率高于鳞癌(P<0.05),鳞癌Cy-fra21-1的阳性率高于腺癌(P<0.05),小细胞癌CA125的阳性率低于腺癌及鳞癌(P<0.05);NSE、Cy-fra21-1、CA199、CA125及CEA联合检测的准确度、灵敏度优于各单独检测(P<0.05)。结论:NSE、Cy-fra21-1、CA199、CA125及CEA联合检测可有效提高肺癌诊断准确率,确定其病理类型,为临床治疗提供参考,具有重要的临床应用价值。
Objective： To investigate the value of combined detection of neuronspecific enolase （ NSE）, Cy - fra21 - 1, carcinoma antigen 199 （ CA199）, carcinoma antigen 125 （ CA125 ） and carcino - embryonic antigen （CEA） in the diagnosis of lung cancer. Methods. Clinical data of 80 cases of lung cancer patients, from January 2015 to January 2017 in our hospital, were retrospectively analyzed and selected in the study group. 80 cases of patients with benign lung disease in the same period were selected as the control group. Serum NSE, Cy -fra21 - 1, CA199, CA125 and CEA detection were made in the two groups. Results ： NSE, Cy - fra21 - 1, CA199, CA125 and CEA in the study group were significantly higher than those in the control group, and the differences between the two groups were significant （ P 〈 0.05 ）. The positive rate of CA125 in adenocarcinoma was significantly higher than that in squamous cell carcinoma （ P 〈 0.05 ）. The positive rate of Cy - fra21 - 1 in squamous cell carcinoma was significantly higher than that in adenocarcinoma （ P 〈 0.05 ）. The positive rate of CA125 in small cell carcinoma was significantly lower than that in adenocarcinoma and squamous cell carcinoma, and the differences were statistically significant （ P 〈 0.05 ）. The accuracy and sensitivity of the combined detection of NSE, Cy - fra21 - 1, CA199, CA125 and CEA were significantly better than those of each individual test, and the differ- ences were statistically significant （P 〈 0.05 ）. Conclusion：Combined detection of NSE, Cy -fra21 -1, CA199, CA125 and CEA can effectively improve the diagnostic accuracy of lung cancer, determine its pathological type, and provide a reference for clinical treatment. It has important clin- ical value.
出处
《包头医学院学报》
CAS
2018年第2期51-52,共2页
Journal of Baotou Medical College
