摘要
目的观察中医辨证疗法联合化疗对老年晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者生活质量和症状负担的影响。方法将63例老年晚期NSCLC患者随机分成治疗组(31例)和对照组(32例)。治疗组采用化疗方案联合中医辨证治疗;对照组仅接受化疗,28天为1个周期,共2个周期。观察两组患者治疗前后肺癌症状量表(LCSS)和生活质量量表(EORTC QLQ-LC43)变化。结果与本组治疗前比较,治疗组治疗后除咯血外,各项LCSS评分均降低(P<0.01),躯体功能、情绪功能、认知功能及总健康状况评分升高(P<0.01,P<0.05),恶心与呕吐、气促、食欲丧失、便秘症状评分降低(P<0.01,P<0.05);对照组治疗后除咯血外,各项LCSS评分均升高(P<0.01),各功能及总健康状况评分降低,疲倦、恶心与呕吐、疼痛、气促、失眠、食欲丧失、便秘、腹泻症状评分升高(P<0.01,P<0.05)。与对照组同期比较,治疗组治疗后除咯血、疼痛两项外,余各项LCSS评分,EORTC QLQ-LC43评分中各功能及总健康状况、疲倦、恶心与呕吐、疼痛、气促、失眠、食欲丧失、便秘、腹泻症状评分均改善(P<0.01,P<0.05)。结论中医辨证疗法联合化疗可减轻老年晚期NSCLC患者的临床症状,改善患者生活质量。
Objective To observe the effect of Chinese medicine therapy based on syndrome differentiation combined with chemotherapy on the quality of life and symptom burden of senile patients with advanced non-small cell lung cancer （NSCLC）. Methods Totally 63 senile patients with advanced NSCLC were randomized into the treatment group（32 cases） and the control group（31 cases）. Patients in the treatment group received Chinese medicine and chemotherapy, while those in the control group re- ceived chemotherapy. The treatment lasted for 2 cycles, and 28 days for 1 cycle. Lung Cancer Symptom Scale（LCSS） and European Organization for Research and Treatment of Lung Cancer Quality of Life Questionnaire LC-43 （EORTC QLQ-LC43） were observed before and after treatment. Results Compared with the same group before treatment, the LCSS score decreased except symptom of hemoptysis （P 〈 0.01 ）, scores for physical functions, emotional functions, cognitive functions and general health condi- tions increased （P 〈0.01, P 〈0.05）; scores of nausea and vomitting, short breath, poor appetite, con- stipation decreased after treatment in the treatment group （P 〈 0.01, P 〈0.05） ; the LCSS scores in-creased except for hemoptysis （P 〈0.01 ）, the score of each function and general health decreased, score of fatigue, nausea and vomitting, pain, short breath, insomnia, poor appetite, constipation, diar- rhea increased after treatment in the control group （P 〈 0.01, P 〈 0.05）. Compared with the control group, better effects were obtained in the treatment group in the aspects of the LCSS score except for hemoptysis and pain, the EORTC QLQ-LC43 score of each function and general health, fatigue, nausea and vomitting, pain, short breath, insomnia, poor appetite, constipation, diarrhea （P 〈0.01, P 〈0.05）. Conclusions Chinese medicine combined with chemotherapy could relieve clinical symptoms of senile advanced NSCLC,and improve the quality of life.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2018年第2期163-167,共5页
Chinese Journal of Integrated Traditional and Western Medicine
基金
上海市科委中医引导项目(No.14401930700)
关键词
中医辨证疗法
晚期非小细胞肺癌
老年
化疗
生活质量
症状负担
Chinese medicine therapy based on syndrome differentiation
advanced non-smallcell lung cancer
senile
chemotherapy
quality of life
symptom burden
