摘要
目的对88例缺铁性贫血(IDA)患者血红蛋白进行毛细血管电泳法分析,为合理诊断和治疗提供思路。方法对88例IDA患者(IDA组)行血常规MCV、MCH、RDW、Hb测定,铁代谢(铁蛋白、总铁结合力)测定及Hb电泳检测,同时设110例为对照组,对以上检测指标结果进行统计分析。结果 Hb电泳分析显示,与正常对照组比较,HbA1c升高,HbA2降低,差异有统计学意义(P<0.05)。与正常对照组比较,IDA组Hb、MCV、MCH、HCT、红细胞脆性及铁蛋白均降低,RDW、总铁结合力升高,差异均有统计学意义(P<0.05)。IDA组HbA1c与血红蛋白、铁蛋白、MCV、MCH、HCT及红细胞脆性呈负相关(P<0.05),与总铁结合力、RDW呈正相关(P<0.05)。HbA2与血红蛋白、铁蛋白、MCV、MCH、HCT及红细胞脆性呈正相关(P<0.05),与总铁结合力、RDW呈负相关(P<0.05)。结论血红蛋白电泳分析显示,IDA患者可高估HbAlc数值,IDA与HbAlc、HbA2关系密切,与MCV及RDW联合检验可作为鉴别2组贫血的指标。
Objective To analyze the detection results of hemoglobin by capillary electrophoresis in patients with iron deficiency anemia（ IDA） in order to provide some ideas for reasonable diagnosis and treatment. Methods Eighty-eight patients with IDA were enrolled as IDA group,at the same time,the other 110 subjects were served as control groups. The MCV,MCH,RDW,Hb,iron metabolism indexes including ferritin and total iron binding capacity were detected and compared between two groups. Results As compared with those in control group,the levels of Hb,MCV,MCH,HCT,erythrocyte fragility,ferritin and HbA2 were significantly decreased in IDA group（ P 〈0. 05）,however,the levels of RDW,total iron binding capacity and HbA1c were significantly increased in IDA group（ P 〈0. 05）. In addition,the levels of HbA1c were negatively correlated with those of Hb,ferritin,MCV,MCH,HCT and erythrocyte fragility in IDA group（ P 〈0. 05）,however,which were positively correlated with those of total iron binding capacity and RDW（ P 〈0. 05）. Moreover the levels of HbA2 were positively correlated with those of Hb,ferritin,MCV,MCH,HCT and erythrocyte fragility（ P 〈0. 05）,however,which were negatively correlated with those of total iron binding capacity and RDW（ P 〈0. 05）. Conclusion The levels of HbAlc are increased in patients with IDA,moreover,HbAlc and HbA2 are closely correlated to IDA,and the combined detection MCV,RDW,HbAlc and HbA2 can be regarded as the indexes to differentiate different kinds of anemia.
出处
《河北医药》
CAS
2018年第3期372-375,共4页
Hebei Medical Journal
关键词
毛细管电泳法
血红蛋白
缺铁性贫血
capillary electrophoresis
hemoglobin
iron deficiency anemia
