摘要
目的:研究高速涡轮牙钻联合微创拔牙刀拔除阻生智齿后局部炎症应激反应及疼痛介质分泌的情况。方法:选择2014年3月~2017年6月在云南省第一人民医院接受阻生智齿拔除的患者作为研究对象,随机分为接受高速涡轮牙钻联合微创拔牙刀拔除阻生智齿的观察组、接受常规骨凿劈冠拔出阻生智齿的对照组。手术前和手术后3d,测定龈沟液中炎症介质、应激介质、疼痛介质的含量。结果:手术后3d,两组患者龈沟液中PTX3、ICAM1、MPO、PGE2、PPARγ、ROS、MDA、5-HT、CGRP、SP、Gal、ATP的含量均高于手术前(P<0.05),GPx、T-AOC的含量均显著低于手术前(P<0.05),且观察组患者龈沟液中PTX3、ICAM1、MPO、PGE2、PPARγ、ROS、MDA、5-HT、CGRP、SP、Gal、ATP的含量均低于对照组(P<0.05),GPx、T-AOC的含量均显著高于对照组(P<0.05)。结论:高速涡轮牙钻联合微创拔牙刀拔除阻生智齿能够减轻局部炎症应激反应、抑制疼痛介质分泌。
Objective:To study the local inflammatory stress response and pain mediator secretion after impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator.Methods:Patients who received impacted wisdom tooth extraction in the First People's Hospital of Yunnan Province between March 2014 and June 2017 were selected as the research subjects and randomly divided into the observation group who accepted impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator and the control group who accepted impacted wisdom tooth extraction with traditional chisel.The contents of inflammatory mediators,stress mediators and pain mediators in gingival crevicular fluid were measured before surgery and 3 days after surgery.Results:3 days after surgery,PTX3,ICAM1,MPO,PGE2,PPARγ,ROS,MDA,5-HT,CGRP,SP,Gal and ATP contents in gingival crevicular fluid of both groups were higher than those before surgery whereas GPx and T-AOC contents were significantly lower than those before surgery,and PTX3,ICAM1,MPO,PGE2,PPARγ,ROS,MDA,5-HT,CGRP,SP,Gal and ATP contents in gingival crevicular fluid of observation group were lower than those of control group whereas GPx and T-AOC contents were significantly higher than those of control group.Conclusion:The impacted wisdom tooth extraction with high-speed turbine drill combined with original luxator can reduce the local inflammatory stress response and inhibit the secretion of pain mediators.
出处
《海南医学院学报》
CAS
2018年第4期523-526,共4页
Journal of Hainan Medical University
基金
昆明市卫生局立项课题(2015-12)~~
关键词
阻生智齿
高速涡轮牙钻
微创拔牙刀
炎症应激反应
疼痛介质
impacted wisdom tooth
high-speed turbine drill
original luxator
inflammatory stress response
pain mediator
