摘要
探讨外周血CD4~＋、CD8~＋T水平与慢性乙型肝炎不同中医体质的关系。选取2016年2月至2017年3月在我院治疗的慢性乙型感染患者143例,其中平和质35例、气虚质40例、阴虚质21例、湿热质20例,气郁质16例、其他11例,采用流式细胞仪检测外周血T淋巴细胞亚群。不同中医体质患者性别、年龄、病程及HBV-DNA含量比较差异无统计学意义（p〉0.05）;平和质患者AST为342.21（142.42,513.46）U/L,明显低于其他患者（p〈0.05）;气虚质患者AST为512.40（322.81,726.50）U/L,明显高于其他患者（p〈0.05）;气郁质及其他体质患者ALT分别为381.64（210.41,501.72）U/L和370.43（200.41,470.63）U/L,明显高于平和质、气虚质、阴虚质和湿热质患者（p〈0.05）;平和质和气虚质患者外周血CD4~＋T细胞分别为（39.10±2.01）%和（39.10±2.01）%,明显低于阴虚质、湿热质、气郁质及其他体质患者（p〈0.05）;气郁质及其他体质患者CD8~＋T细胞分别为（25.43±1.33）%和（25.24±1.31）%,明显低于平和质、气虚质、阴虚质和湿热质患者（p〈0.05）;阴虚质、气郁质及其他体质患者分别为（1.71±0.09）、（1.75±0.08）和（1.78±0.09）,明显高于平和质、气虚质和湿热质患者（p〈0.05）。慢性乙肝不同中医体质与CD4~＋T、CD8~＋T和以及肝功能有密切关系。
The aim of the study was to investigate the relationship between the levels of CD4~＋and CD8~＋T in peripheral blood and the constitutions of traditional Chinese medicine in patients with chronic hepatitis B. 143 patients with chronic HBV infection treated in Chongqing Traditional Chinese Medicine hospital from February 2016 to March 2017 were selected. Among them, there were 35 cases of normal, 40 cases of Qi deficiency, 21 cases of Yin deficiency, 20 cases of dampness heat, 16 cases of Qi depression and 11 cases of other. Peripheral blood T lymphocyte subsets were detected by flow cytometry. The results showed that, there was no significant difference in gender, age,course of disease and HBV-DNA content between different constitutions of traditional Chinese medicine（P〈0.05）; AST in the patients with normal was 342.2（142.42, 513.46） U/L, significantly lower than that of other patients（P〈0.05）;the AST in patients with Qi deficiency was 512.40（322.81, 726.50） U/L, significantly higher than that of other patients（P〈0.05）; the ALT of patients with Qi depression and other constitutions was 381.64（210.41, 501.72） U/L and 370.43（200.41, 470.63） U/L, respectively, which were significantly higher than that of normal, Qi deficiency, Yin deficiency and dampness heat（P〈0.05）; the CD4~＋T cells in peripheral blood of patients with normal and Qi deficiency was（39.10±2.01）% and（39.10±2.01）%, respectively, which was significantly lower than that of Yin deficiency, dampness heat, Qidepression and other constitutions（P〈0.05）; the CD8~＋T cells in patients with Qi depression and other constitutions was（25.43±1.33）% and（25.24±1.31）%, successively, which was significantly lower than that of normal, Qi deficiency, Yin deficiency and dampness heat（P〈0.05）; the CD4~＋/CD8~＋of patients with Yin deficiency, Qi depression and other constitutions was（1.71±0.09）,（1.75±0.08） and（1.78±0.09）, successively, which was significantly higher than that of normal, Qi deficiency and dampness heat（P〈0.05）. Chronic hepatitis B patient in different TCM constitutions might have close relationships with CD4~＋T, CD8~＋T, CD4~＋/CD8~＋and liver function.
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2018年第1期129-135,共7页
Genomics and Applied Biology
基金
重庆市中医院资助
关键词
慢性乙型肝炎
中医体质
T淋巴细胞亚群
肝功能
Chronic hepatitis B, Constitution of traditional Chinese medicine, T lymphocyte subsets, Liver function
