摘要
甲羟戊酸途径是一个高度保守的代谢途径,能够合成对细胞生长至关重要的异戊二烯类化合物,如焦磷酸盐类等。现在越来越多的研究认为这条代谢途径与肿瘤细胞的过度活跃相关,是肿瘤治疗的重要靶点,而该途径上游产物的累积和下游产物的缺失也对肿瘤的形成有着重要作用。因此,通过免疫监控,甲羟戊酸途径能直接或间接的影响肿瘤的生物学。本文综述他汀类和二膦酸盐类药物通过阻断甲羟戊酸途径影响肿瘤生物学的作用机制。
The mevalonate pathway is a highly conserved metabolic approach, which provides vital isoprenoid building blocks for cell growth, such as prenyl pyrophosphates. Now increasing researchers believe that mevalonate pathway is associated with the hyperactivity of tumor cells, which is one of the important targets for cancer therapy. The upstream accumulation of intermediate and its downstream depletion in cells mevalonate pathway can lead to some cancers. Therefore, by immune surveillances, the mevalonate pathway can directly or indirectly influence tumor biology. This paper summarizes the anti-tumor mechanism of statins and bisphosphonates by blocking mevalonate pathway.
出处
《世界临床药物》
CAS
2018年第1期59-61,72,共4页
World Clinical Drug
基金
上海市自然科学基金项目(编号:12ZR1429500)
教育部留学回国人员科研启动基金资助项目(编号:2015311)
上海青年医师培养资助计划基金项目(编号:2014118)
上海市杨浦区卫计委好医师计划基金项目(编号:201742)
上海市杨浦区科委
卫计委科研课题(委级)(编号:YP15M01)
同济大学附属杨浦医院晨光计划(编号:Ye1201613)
同济大学附属杨浦医院院级课题(编号:Se1201612)
