摘要
目的探讨醒脑静注射液联合注射用盐酸甲氯芬酯治疗急性酒精中毒的临床疗效。方法选取2016年6月—2017年6月赤峰市医院收治的急性酒精中毒患者117例作为研究对象,所有患者在随机分组的原则下分为对照组(58例)和治疗组(59例)。对照组静脉滴注注射用盐酸甲氯芬酯,0.2 g加入到5%葡萄糖溶液250 mL中,3次/d。治疗组在对照组的基础上静脉滴注醒脑静注射液,20 mL加入到5%葡萄糖溶液500 mL中,1次/d。两组患者均治疗3 d。观察两组的临床疗效,比较两组的苏醒时间、中毒症状消失时间、运动功能恢复时间、氧代谢指标、血清氧化应激指标和苏醒后不适症状。结果治疗后,对照组和治疗组的总有效率分别为81.03%、96.61%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组苏醒时间、中毒症状消失时间和运动功能恢复时间明显短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血氧饱和度、动脉血氧、超氧化物歧化酶和谷胱甘肽过氧化物酶水平均显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗苏醒后,对照组和治疗组的不适症状发生率分别为43.10%、13.56%,两组比较差异有统计学意义(P<0.05)。结论醒脑静注射液联合注射用盐酸甲氯芬酯治疗急性酒精中毒具有较好的临床疗效,能缩短苏醒时间、中毒症状消失时间和运动功能恢复时间,调节氧代谢指标和血清氧化应激指标,减轻患者苏醒后的不适症状,具有一定的临床推广应用价值。
Objective To explore the clinical effect of Xingnaojing Injection combined with Meclofenoxate Hydrochloride for injection in treatment of acute alcoholism. Methods Patients（117 cases） with acute alcoholism in Chifeng Municipal Hospital from June 2016 to June 2017 were randomly divided into the control group（58 cases） and the treatment group（59 cases）. Patients in the control group were iv administered with Meclofenoxate Hydrochloride for injection, 0.2 g added into 5% glucose solution 250 mL, three times daily. Patients in the treatment group were iv administered with Xingnaojing Injection on the basis of the control group, 20 mL added into 5% glucose solution 500 mL, once daily. Patients in two groups were treated for 3 d. After treatment, the clinical efficacies were evaluated, and revive time, poisoning symptoms disappeared time, exercise function recovery time, oxygen metabolism indexes, serum oxidative stress indexes, and discomfort symptoms after awakening in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.03% and 96.61%, respectively, and there was difference between two groups（P〈0.05）. After treatment, revive time, poisoning symptoms disappeared time, and exercise function recovery time in the treatment group were obviously shorter than those in the control group, and there was difference between two groups（P〈0.05）. After treatment, the levels of blood oxygen saturation, arterial oxygen content, superoxide dismutase, and glutathione peroxidase in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in treatment group were significantly higher than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the incidence of discomfort symptoms in the control and treatment groups were 43.10% and 13.56%, respectively, and there was difference between two groups（P〈0.05）. Conclusion Xingnaojing Injection combined with Meclofenoxate Hydrochloride for injection has clinical curative effect in treatment of acute alcoholism, can shorten revive time, poisoning symptoms disappeared time, and exercise function recovery time, regulate oxygen metabolism indexes and serum oxidative stress indexes, relieve the discomfort symptoms after awakening, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2018年第1期152-155,共4页
Drugs & Clinic
关键词
醒脑静注射液
注射用盐酸甲氯芬酯
急性酒精中毒
氧代谢指标
血清氧化应激指标
Xingnaojing Injection
Meclofenoxate Hydrochloride for injection
acute alcoholism
oxygen metabolism index
serumoxidative stress index
