摘要
目的调查骨感染患者的感染情况并探讨感染患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)与C-反应蛋白(CRP)水平变化情况。方法选取医院2013年1月-2016年12月收治的骨科患者243例为研究对象,对其感染发生情况、导致感染的相关因素和致病菌及炎症因子指标等进行观察。结果 243例骨科患者发生骨感染的患者32例,骨感染发生率为13.17%;共培养分离病原菌54株,其中革兰阴性菌35株占64.81%,革兰阳性菌15株占27.78%;病程、手术治疗和住院时间是骨科患者骨感染的相关因素(P<0.001);骨感染患者的TNF-α、CRP、IL-12、IL-18、IL-6和IL-8分别为(5.99±1.31)mg/L、(24.11±7.61)、(134.23±43.13)、(253.11±50.12)、(99.24±38.41)和(96.93±40.32)pg/ml均高于未感染患者(P<0.001)。结论骨感染患者的血清TNF-α、CRP及相关临床因子水平会升高,应针对上述临床特征给予患者针对性的干预措施。
OBJECTIVE To investigate the infection situations and changes of serum tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）and C-reactive protein（CRP）in patients with orthopedic infections.METHODS A total of243 cases of orthopedic patients admitted to hospital from Jan.2013 to Dec.2016 were selected as the research objects.The infection situations,risk factors of infections and pathogens and the clinical inflammatory mediators of infected patients were taken for observation.RESULTS Totally 32 cases were with bone infections in the 243 cases of orthopedic patients,and the incidence of bone infection was 13.17%.Totally 54 strains of pathogens were detected,of which 35 strains were gram-negative bacteria accounting for 64.81%and 15 strains were gram-positive bacteria accounting for 27.78%.The duration of treatment,surgical treatment and hospitalization were the independent risk factors for bone infections in orthopedic patients（P〈0.001）.The levels of TNF-α,CRP,IL-12,IL-18,IL-6 and IL-8 in patients with bone infection were（5.99±1.31）mg/L,（24.11±7.61）,（134.23±43.13）,（253.11±50.12）,（99.24±38.41）and（96.93±40.32）pg/ml,which were significantly higher than those in non-infected patients（P〈0.001）.CONCLUSION The levels of serum tumor necrosis factor-α,C-reactive protein and related clinical factors in patients with bone infection are significantly increased.In the practice,patient-specific interventions should be given to the above-mentioned clinical features.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第4期559-562,共4页
Chinese Journal of Nosocomiology
