摘要
目的研究白大衣高血压(WCH)血浆肾素活性和醛固酮水平对白大衣高血压血压变异性的影响。方法选取2013年1月—2016年12月在高血压科门诊或住院的白大衣高血压(WCH)患者150例,轻中度原发性高血压(EHT)患者161例,正常血压对照组(NTG)167例,每组均监测动态血压,并进行血浆肾素活性(PRA)、醛固酮(ALDO)测定。结果 Pearson相关分析结果显示,WCH组全天收缩压标准差(ADSSD,r=0.644),全天舒张压标准差(ADDSD,r=0.707)与PRA呈正相关(均P<0.001)。ADDSD(r=0.861)与ALDO呈正相关(P<0.001)。ADSSD(r=0.308)与ALDO的相关没有统计学意义(P=0.072);EHT组和NTG组ADSSD(r=0.125、-0.167),ADDSD(r=0.036、-0.265)与PRA的相关无统计学意义(P=0.560、0.338、0.794、0.124)。EHT组和NTG组ADSSD(r=-0.027、-0.024),ADDSD(r=0.009、0.012)与ALDO的相关无统计学意义(P=0.860、0.890、0.956、0.920)。结论白大衣高血压患者的血压变异性与PRA相关。
Objective To study the effects of plasma renin activity and aldosterone level on blood pressure variability in white coat hypertension（ WCH）. Methods A total of 150 patients with WCH,161 patients with mild to moderate essential hypertension（ EHT）,167 cases of normotension group（ NTG） were chosen from outpatient department or inpatient department from January,2013 to December,2016. Ambulatory blood pressure,plasma renin activity（ PRA） and aldosterone（ ALDO） were monitored in each group. Results Pearson correlation analysis showed that All day systolic blood pressure standard deviation（ ADSSD,r = 0. 644）,and All day diastolic blood pressure standard deviation（ ADDSD,r = 0. 707） in WCH group were positively correlated with PRA（ all P 〈0. 001）. ADDSD（ r = 0. 861） was positively correlated with ALDO（ P 〈0. 001）. The correlation between ADSSD（ r = 0. 308） and ALDO was not statistically significant（ P = 0. 072）; the correlations between ADSSD（ r = 0. 125,-0. 167）,ADDSD（ r = 0. 036,-0. 265）and PRA in EHT and NTG group were not statistically significant（ P = 0. 560,0. 338,0. 794,0. 124）. The correlations between ADSSD（ r =-0. 027,-0. 024）,ADDSD（ r = 0. 009,0. 012） and ALDO in EHT and NTG group were not statistically significant（ P = 0. 860,0. 890,0. 956,0. 920）. Conclusion Blood pressure variability in patients with WCH is associated with PRA.
出处
《中华全科医学》
2018年第3期423-426,共4页
Chinese Journal of General Practice
基金
河南省郑州市普通科技攻关计划项目(121PPTGG492-1)
关键词
白大衣高血压
血浆肾素活性
血压变异性
White coat hypertension
Plasma renin activity
Blood pressure variability
