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老年人呼吸系统致病菌定植与感染研究进展 被引量:5

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摘要 呼吸系统感染是老年人最常见的感染性疾病,针对致病病原体的合理抗感染治疗是影响预后的重要原因。抗菌药物的广泛、不合理使用导致越来越多的细菌耐药及致病菌定植问题的出现,抗感染治疗面临重大挑战,新的治疗方案及新型抗菌药物的研发迫在眉睫。致病病原体在呼吸系统定植与感染密切相关,是一个动态发展的过程,受气道局部环境、营养状况、机体免疫等多重因素影响,控制细菌的定植过程能有效减少感染性疾病的发作,且临床上不能准确识别细菌定植或感染是抗菌药物滥用的重要医源性原因。因此,探讨细菌定植机制和鉴别细菌的定植与感染状态对合理应用抗菌药物及改善呼吸系统感染性疾病的远期预后具有重要临床意义。
出处 《医药导报》 CAS 北大核心 2018年第3期311-314,共4页 Herald of Medicine
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