摘要
目的优选检测护肝片中硒的前处理条件。方法以盐酸浓度、水浴时间和铁氰化钾溶液浓度为主要影响因素,以硒含量为评价指标,星点设计-效应面法优选前处理条件。结果最佳前处理条件为盐酸6 mol·L-1,水浴加热30 min,铁氰化钾溶液浓度20%。结论星点设计-效应面法优选前处理条件预测性好,合理可行。
Objective To optimize the pretreatment conditions in the detection of selenium from hugan tablets.Methods The main influential factors of pretreatment conditions included concentration of hydrochloric acid,time in water bath and concentration of potassium ferricyanide solution.The extraction effect was evaluated with the content of selenium.Pretreatment conditions were optimized by central composite design-response surface methodology. Results The best pretreatment conditions was 6 mol·L-1 hydrochloric acid,30 minutes of bathing in water bath,20% potassium ferricyanide solution. Conclusion The central composite design-response surface methodology is highly predictive,reasonable and feasible.
出处
《医药导报》
CAS
北大核心
2018年第3期351-355,共5页
Herald of Medicine
关键词
护肝片
硒
星点设计
效应面法
前处理条件
Hugan tablets
Selenium
Central composite design
Response surface methodology
Pretreatment condition
