摘要
目的观察通腑活血汤配合谷氨酰胺对胃癌根治术后氧化应激、肠黏膜屏障功能及胃肠功能恢复的影响。方法将80例胃癌根治术后患者随机分为2组,对照组40例予谷氨酰胺颗粒治疗,治疗组40例在对照组治疗基础上加通腑活血汤治疗,疗程7 d。比较2组术后及用药7 d后症状(腹胀、呃逆、腹痛、便秘、肠鸣音减弱)积分变化,临床结局胃肠功能恢复情况和一般临床预后情况,检测比较2组术后及用药7 d后血清超氧化物歧化酶(SOD)、丙二醛(MDA)、二胺氧化酶及D-乳酸水平变化。结果 2组用药7 d后腹胀、呃逆、腹痛、便秘、肠鸣音减弱积分及总分均较本组术后明显降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗组胃肠功能恢复情况及一般临床结局优于对照组(P<0.05)。2组用药7 d后血清MDA、二胺氧化酶及D-乳酸水平均较本组术后显著降低(P<0.05),SOD水平显著升高(P<0.05),且2组组间比较差异均有统计学意义(P<0.05)。结论通腑活血汤配合谷氨酰胺能够显著抑制胃癌根治术后患者氧化应激,保护肠黏膜屏障功能,从而促进术后胃肠功能的恢复,改善患者预后,值得临床应用。
Objective To observe the effects of Tongfu Huoxue decoction combined with Glutamine on the recovery of oxidative stress,intestinal mucosal barrier function and gastrointestinal function after radical operation of gastric cancer. Methods 80 patients with radical operation of gastric cancer were randomly divided into two groups,40 cases in control group were treated by Glutamine granules,and 40 cases in treatment group were treated by Tongfu Huoxue decoction on the basis of the control group,the treatment course was 7 d. The changes of symptom integrals including abdominal distension,hiccup,abdominal pain,constipation and hypoactive bowel sounds,and clinical outcome of gastrointestinal function recovery and general clinical prognosis were compared between the two groups after operation and taking medication for 7 d. The levels of serum superoxide dismutase( SOD),malondialdehyde( MDA),diamine oxidase and D-lactic acid were measured and compared between the two groups after operation and taking medication for 7 d. Results The symptom integrals including abdominal distension,hiccup,abdominal pain,constipation and hypoactive bowel sounds and total integrals after taking medication for 7 d were significantly lower than after operation in two groups( P < 0. 05),and which in treatment group were lower than that in control group( P< 0. 05). The clinical outcome of gastrointestinal function recovery and general clinical prognosis in treatment group were superior to that in control group( P < 0. 05). The levels of MDA,diamine oxidase and D-lactic acid were after taking medication for 7 d were significantly lower than after operation in two groups( P < 0. 05),and SOD was higher with statistical differences between two groups( P < 0. 05). Conclusion Tongfu Huoxue decoction combined with Glutamine can significantly inhibit the oxidative stress of patients after radical operation of gastric cancer,and protect the intestinal mucosal barrier function,thus promoting the recovery of postoperative gastrointestinal function and shortening the hospital stay,which is worthy of clinical recommendation.
出处
《河北中医》
2018年第1期68-72,共5页
Hebei Journal of Traditional Chinese Medicine
基金
2015年度上海市自然科学基金项目(编号:15ZR1441800)
关键词
胃肿瘤
氧化性应激
谷氨酰胺
中西医结合疗法
Gastric neoplasm
Oxidizability stress
Malondialdehyde
Combine traditional Chinese and western medicine therapy
