摘要
目的分析自体富血小板凝胶治疗难治性糖尿病皮肤溃疡的临床疗效及对血清炎症因子的影响。方法选择糖尿病皮肤溃疡患者160例,随机分成对照组和研究组各80例。对照组患者接受常规碘伏消毒治疗,研究组在常规治疗基础上给予自体富血小板凝胶进行治疗。比较2组患者治疗前后炎症因子、溃疡面积及临床疗效。结果治疗后,2组患者的TNF-α、IL-6水平均显著低于治疗前,且研究组显著低于对照组(P<0.05);治疗后,2组患者溃疡面积均显著小于治疗前,且研究组显著小于对照组(P<0.05);研究组治疗总有效率为93.8%,显著高于对照组的65.0%(P<0.05)。结论自体富血小板凝胶能够有效降低TNF-α、IL-6等炎性因子水平,减小糖尿病皮肤溃疡面积,提高患者生活质量。
Objective To analyze clinical efficacy of autologous platelet-rich gelatin in the treatment of patients with refractory diabetic skin ulcer and its effect on serum inflammatory cytokines. Methods Totally 160 patients with refractory diabetic skin ulcer were selected and randomly divided into control group and study group, 80 cases in each group. The patients in the control group were treated with iodophor disinfection, and the patients in the study group were treated with autologous platelet-rich gels on the basis of routine treatment. Inflammatory factors, change of ulcer area and clinical efficacy were observed and compared. Results After the treatment, the levels of TNF-ct and IL-6 in both groups were significantly lower than those before treatment, and the indexes in study group were significantly lower than control group （ P 〈 0.05 ）. The ulcer area in both groups were sig- nificantly less than that before treatment, and the ulcer area in study group was significantly smaller than the control group （P 〈 0.05）. The total effective rate of the study group was 93.8% , which was significantly higher than 65.0% of the control group （P 〈 0.05 ）. Conclusion Autologous platelet- rich gelatin can effectively reduce the levels of inflammatory cytokines such as TNF-α and IL-6, re- duce the area of diabetic skin ulcers, and improve quality of life.
出处
《实用临床医药杂志》
CAS
2018年第5期26-28,31,共4页
Journal of Clinical Medicine in Practice
关键词
自体富血小板凝胶
糖尿病
皮肤溃疡
疗效
炎症因子
autologous platelet-rich gelatin
diabetic
skin ulcers
efficacy
inflammatory cytokines
