摘要
PTEN基因是易突变的抑癌基因,其编码的PTEN蛋白具有蛋白磷酸酶与脂质磷酸酶双重酶活性,通过复杂的信号转导通路参与调节机体生长代谢。PTEN能阻断PI3K/AKT信号通路,激活FoxO1或使mTORC失活,调控SREBP和Maf1,进而影响Fasn、Acc等酶类的表达,抑制脂质生成;反过来,不饱和脂肪酸又能通过NF-κB途径影响PTEN的表达;同时PTEN也会影响糖代谢。本文主要就PTEN结构特点、生物学功能,特别是PTEN在脂质代谢方面的研究进展进行综述,旨在为了解肥胖、癌症等脂质代谢紊乱相关性疾病的发生发展,寻求疾病的治疗药物和方法积累基础理论资料。
PTEN protein, encoded by a mutable tumor suppressor gene PTEN, has dual activities of protein phosphatase and lipid phosphatase. It is involved in the regulation of cell growth and metabolism through the complicated signal transduction pathways. PTEN can block PI3 K/AKT signaling pathway, which results in the activation of FoxO1 and inactivation of mTORC. The expressions of fatty synthase enzymes are then affected by the regulated SREBP and Maf1, which results in the inhibition of lipogenesis. Unsaturated fatty acids, in turn, can affect the expression of PTEN through the NF-κB pathway. Meanwhile, PTEN can also regulate the sugar metabolism. In this paper, the recent progresses of PTEN in its structure, biological function and especially in lipid metabolism were reviewed.
出处
《生命的化学》
CAS
CSCD
2017年第6期901-906,共6页
Chemistry of Life
基金
国家自然科学基金项目(81171564
81521091)
