摘要
目的:通过对微乳处方的筛选和优化,确定平胃微乳的处方组成,并进行药效学验证。方法:通过单因素考察,确定混合挥发油、药渣水提物及甘草皂苷用量的3个水平;以溃疡抑制率为指标,进行正交试验以确定处方中各组分的用量;并用吲哚美辛造成的小鼠胃溃疡模型和盐酸乙醇法造成的溃疡大鼠模型进行药效学验证。结果:确定处方中各组分的用量为:苍术、厚朴、陈皮SFE-CO_2混合挥发油0.8 ml,甘草皂苷60 mg,苍术、厚朴、陈皮SFE-CO_2提取后水提物2.0 g。结论:平胃微乳制备工艺可行,具有良好的抗溃疡作用,与阳性对照药三九胃泰相当。
Objective： To determine the compositions of Pingwei microemulsion through the formula screening and optimization,and carry out the pharmacodynamic validation. Methods： Three levels of mixed volatile oil,dregs water extract and glycyrrhizin were determined by single factor investigation. With the ulcer inhibition rate as an indicator,the orthogonal test was carried out to determine the amount of each component in the formula,and the pharmacodynamic validation was performed on the mouse model of gastric ulcer induced by indomethacin and the rat model of ulcer induced by ethanol hydrochloride. Results： The amount of each component in the formula was determined as follows： SFE-CO_2 mixed volatile oil of Atractylodes Lancea（ Thunb.） DC.,Magnolia officinalis Rehd. Et Wils. and Pericarpium Citri Reticulatae was 0. 8 ml,glycyrrhizin was 60 mg,and the water extract after SFE-CO_2 extraction of Atractylodes Lancea（ Thunb.） DC.,Magnolia officinalis Rehd. Et Wils. and Pericarpium Citri Reticulatae was 2. 0 g. Conclusion： The preparation process of Pingwei microemulsion is feasible,and Pingwei microemulsion has a good anti-ulcer effect,equalling to the positive control Sanjiuweitai.
出处
《中国药师》
CAS
2018年第2期237-241,共5页
China Pharmacist
关键词
平胃散
微乳
处方
药效学
Pingwei powder
Microemulsion
Formula
Pharmacodynamics
