摘要
目的探讨体内血清同型半胱氨酸(homocysteine,Hcy)水平与精神分裂症患者的认知能力之间的关系。方法选取112例首发精神分裂症患者做实验组,100例健康志愿者做对照组。比较两组血清Hcy水平,高同型半胱氨酸(HHcy)检出率。对实验组进行阳性与阴性症状量表(Positive and Negative Symptoms Scale,PANSS)评价患者精神状况。采用威斯康星卡片(Wisconsin Card Sorting Test,WCST)、精神分裂症认知功能测试共识版(MATRICS Consensus Cognitive in Schizophrenia,MCCB)评价实验组患者中HHcy患者与非HHcy患者的认知能力。结果实验组血浆同型半胱氨酸水平明显高于对照组,差异有统计学意义(P<0.01)。两组VB12(vitamin B12)水平对比,实验组明显低于对照组,差异有统计学意义(P<0.05)。而叶酸水平则无显著差异,(P>0.05)。实验组中HHcy(高同型半胱氨酸)患者的MCCB评分总分为(89.22±3.06)分,而非HHcy(非高同型半胱氨酸)总分为(96.11±2.74)分,差异有统计学意义(P<0.05)。对各组WCST各项分值进行比较,HHcy患者完成分类数、正确应答数均明显低于非HHcy患者,差异有统计学意义(P<0.05)。而余下三项HHcy患者则明显高于非HHcy,差异有统计学意义(P<0.05)。结论血清Hcy升高可作为首发精神分裂症的实验室辅助诊断指标之一。
Objective To detect the relationship between cognitive ability and the level of serum homocysteine in patients with first-episode schizophrenia. Methods 112 hospitalized patients with first-episode schizophrenia in our hospital and 100 cases healthy people were selected as the observation group and the control group respectively. The detection rale of high homocysteine septicemia （ HHcy ） and serum Hey level were compared between the observation group and the control group. Psychiatric symptoms were assessed by PANSS. Cognitive function was assessed by WSCT and MCCB. Results The serum Hcy level in observation group was significantly higher than that in control group （P〈 0. 01 ） . The serum VB 12 （vitamin B 12） level in control group was significantly higher than that in observation group （P 〈 0 . 05 ） . The level of folic acid in these groups has no statistically significant （P 〉 0.05 ） . By comparing the total scores of MCCB of different Hcy level in observation group, score of HHcy patients （ 89.22 ± 3.06 ） was significantly lower than that of non-Hcy patients （96.11 ± 2.74）（P 〈 0.05 ）. By comparing scores of WCST, Co, Re significantly increased in the non-HHcy group than those in the HHcy group, Re, Rp, nRp decreased significantly （P〈0.05）. Conclusion The detection rate of HHcy and serum Hcy levels can be used as the laboratory assistant diagnostic indexes of the first episode schizophrenia.
出处
《国际精神病学杂志》
2018年第1期36-38,共3页
Journal Of International Psychiatry
