摘要
目的：探讨益气祛风汤雾化吸入治疗肺气虚寒型鼻鼽和生活质量改善作用及对白细胞介素-4（IL-4）,IL-5,IL-13,半胱氨酰白三烯（CYs-LTs）等因子的影响。方法：150例符合要求的患者,按1∶1比例随机分为对照组和观察组各75例。对照组采用糠酸莫米松鼻喷雾剂,每个鼻孔1喷,每晚1次;观察组采用益气祛风汤雾化吸入,1次/d,20 min/次。两组疗程均为14 d。进行治疗前后主要症状评分和鼻结膜炎生活质量调查问卷（RQLQ）评分;测量治疗前后鼻阻力;检测治疗前后血清总IgE水平（TIgE）,特异性IgE（sIgE）,IL-4,IL-5,IL-13,CYs-LTs水平;进行治疗后鼻腔分泌物嗜酸性粒细胞（EOS）检查。结果：观察组临床疗效有效率为91.55%,高于对照组的78.57%（χ^2=4.683,P〈0.05）;治疗后观察组主要症状（鼻塞、鼻痒、喷嚏、流涕、眼痒/异物感/眼红、流泪）评分及总积分均低于对照组（P〈0.01）;治疗后观察组患者RQLQ量表各维度评分和总分均低于对照组（P〈0.01）;治疗后观察组患者鼻阻力低于对照组（P〈0.01）;治疗后观察组患者TIgE,sIgE水平均低于对照组（P〈0.01）;治疗后观察组患者血清CYs-LTs,IL-4,IL-5,IL-13水平均低于对照组（P〈0.01）。结论：益气祛风汤雾化吸入治疗肺气虚寒型鼻鼽患者,能减轻临床症状,降低鼻阻力,提高患者的生活质量,能抑制鼻炎症状,减轻机体的致敏程度,临床疗效优于糠酸莫米松鼻喷雾剂。
Objective： To discuss the clinical effect of atomization and inhalation therapy of Yiqi Qufeng decoction on symptoms and quality of life in patients with Biqiu（allergic rhinitis,AR） and deficiency-cold of lung Qi,as well as its effects on levels of interleukin-4（IL-4）,IL-5,IL-13 and cysteinyl leukotrienes（CYs-LTs）.Method： One hundred and fifty patients were randomly divided into control group（75 cases） and observation group（75 cases） by random number table.Patients in control group got mometasone furoate aqueous nasal spray,1 spray/nostril,once for every night.Patients in observation group got atomization and inhalation therapy of Yiqi Qufeng decoction,1 time/day,20 min/time.The treatment course was 14 days for both groups.Before and after treatment,main symptom scores and rhinoconjunctivitis quality of life questionnaire（RQLQ） were graded.Nose resistance and levels of total IgE（TIgE）,specificity（s IgE）,IL-4,IL-5,IL-13 and CYs-LTs were detected.The level of eosinophils was tested after treatment.Result： The total effective rate was 91.55% in observation group.Higher than 78.57% in control group（χ^2= 4.683,P〈0.05）.After treatment,the item scores and the total sores of main symptoms such as nasal congestion,nasal itching,sneeze,runny nose,itchy eyes,foreign body sensation,red eyes and tears in observation group were lower than those in control group（P〈0.01）.Dimensional scores and the total score of RQLQ in observation group were all lower than those in control group after treatment（P〈0.01）.Nose resistance in observation group was lower than that in control group（P〈0.01）,and levels of TIgE,s IgE,CYs-LTs,IL-4,IL-5 and IL-13 were lower than those in control group（P〈0.01）.Conclusion： Atomization and inhalation therapy of Yiqi Qufeng decoction in patients with Biqiu can relieve clinical symptoms and degree of sensitization,decrease nose resistance,improve quality of life,and inhibit inflammation symptoms,and its clinical efficacy was better than that of mometasone furoate.
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2018年第4期197-202,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
重庆市卫生和计划生育委员会中医药科研项目(20150240)
关键词
鼻鼽
变应性鼻炎
肺气虚寒
益气祛风汤
雾化吸入
生活质量
鼻阻力
Biqiu
allergic rhinitis
deficiency-cold of lung Qi
Yiqi Qufeng decoction
atomization and inhalation therapy
quality of life
nose resistance
