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中心性浆液性脉络膜视网膜病变患者荧光素眼底血管造影及预后特征相关性分析 被引量:8

Fundus fluorescein angiography characteristics and its association with the prognosis in patients with central serous choroidal retinopathy
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摘要 目的探究中心性浆液性脉络膜视网膜病变(CSC)患者荧光素眼底血管造影(FFA)与预后不良的相关因素。方法收集2013年12月至2016年12月我院收治的76例CSC患者的性别、年龄、体重(BMI)、文化水平、病程以及FFA检查结果(渗漏类型、面积和分布情况),规律治疗6个月复查视力和FFA,统计患者预后及病情转归。分析CSC预后不良的危险因素及与FFA诊断类型的相关性。结果各因素中年龄、病程、渗漏类型、渗漏位置和渗漏面积可影响CSC预后,各因素不同组别预后不良比率差异有统计学意义(χ~2=14.82、7.61、15.77、20.46和14.72,P均<0.05);而性别、BMI、病眼数量和分布、文化水平不影响CSC预后,各因素不同组别预后不良比率差异无统计学意义(χ~2=0.34、2.02、2.89和1.27,P均>0.05)。对年龄、病程、渗漏类型、渗漏位置和渗漏面积进行Logistic回归分析结果显示:年龄>40岁,病程>12个月,墨渍样、多病灶渗漏类型,渗漏面积>1/3 PD,渗漏位置靠近黄斑区域是CSC患者预后不良的独立性危险因素。影响CSC预后的危险因素中,病程、渗漏类型、渗漏位置和渗漏面积与预后不良呈显著的线性正相关关系(P<0.05),而年龄与预后不良无明显线性关系(P>0.05)。结论多种因素可影响CSC患者预后,FFA诊断类型与CSC预后有显著的相关性,其中渗漏类型、面积和位置与CSC预后不良呈线性相关关系,在临床上可作为预测CSC预后的指标。 Objective To investigate the correlation between fundus fluorescein angiography(FFA) and unfavorable prognosis in patients with central serous choroidal retinopathy( CSC). Methods Sex,age,BMI,educational level,course of disease,FFA examination results( leakage type,area and distribution) and the re-examination of vision and FFA6 months after regular treatment were analyzed for 76 CSC patients who were treated in our hospital between December 2013 and December 2016. The CSC risk factors for poor prognosis and correlations with FFA were analyzed. Results Age,disease course,and FFA presentation( type,location and area of the leakage) are associated with the prognosis of CSC.There were significant differences in the rate of poor prognosis between different groups that had stratified levels of these factors( χ^2= 14. 82,7. 61,15. 77,20. 46 and 14. 72,respectively; P〈0. 05). Sex,BMI,the number and distribution of the eye disease,and education level did not affect the prognosis. Logistic regression analysis identified following independent risk factors: age 40 years or older,disease last for 12 months or longer,multifocal ink blotting type of the leakage,leakage area 1/3 PD,or located near the macular region. Disease course,type,location and area of the leakage also showed a positive linear correlation with poor prognosis( P〈0. 05). Conclusions Many factors can influence the prognosis of patients with CSC. There is a positive correlation between the FFA findings and prognosis of CSC. The type,area and location of the leakage are linearly correlated to prognosis. FFA findings can be used to predict the outcome of the disease and treatment.
出处 《临床眼科杂志》 2018年第1期18-21,共4页 Journal of Clinical Ophthalmology
关键词 中心性浆液性脉络膜视网膜病变 荧光素眼底血管造影 预后不良 相关性 危险因素 Central serous retinopathy Fundus fluorescein angiography Poor prognosis Correlation Risk factors
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