摘要
目的探讨苦参碱注射液辅助CAG方案治疗儿童急性髓系白血病的疗效及对患者血清中白细胞介素(IL)-2和IL-10水平的影响。方法将急性髓性白血病患儿78例随机分为对照组39例和观察组39例。对照组采取CAG方案治疗,观察组在对照组基础上予苦参碱注射液静脉滴注。比较2组中医临床症状评分、不良反应情况及临床疗效及死亡率等。检测2组患儿血清中白细胞介素(IL)-2和IL-10的水平。结果治疗后,观察组患儿的中医临床症状指标评分显著低于对照组(P<0.01)。观察组患儿的总有效率为79.49%,显著高于对照组53.85%(P<0.05)。观察组患儿的不良反应发生率均低于对照组,其中厌食、肝损伤和中性粒细胞减少发生率显著低于对照组(P<0.05)。治疗后,观察组患者血清中IL-2显著升高、IL-10水平显著降低,且与对照组差异有统计学意义(P<0.01)。结论苦参碱注射液辅助CAG方案治疗儿童急性髓系白血病的疗效明显,安全性好,且可提高患儿血清中IL-2水平及降低IL-10水平。
Objective To observe the efficacy of matrine injection combined with CAG regimen for children with acute myeloid leukemia and the influence on sermn levels of IL-2 and IL-10. Methods 78 cases with acute myeloid leukemia were randomly divided the control group（39 group） and the observation group（39 group）. The control group were treated with CAG regimen. Based on the control group, the observation group was treated with matrine injection. Scores of symptoms of traditional Chinese medicine, efficacy, and untoward effect were compared between the 2 groups. Serum levels of IL-2 and IL-10 were detected in both groups. Results After treatment, scores of symptoms of traditional Chinese medicine of the observation group were obviously lower than the control group（ P 〈 0. 01 ）. Total efficacy of the observation group was 79.49%, which was higher than that of the control group as 53.85% （P 〈 0.05 ）. Side effects of the observation group was lower than the control group, among which apocleisis,liver injury, and neutropenia were remarkably lower（ P 〈 0. 05 ）. Serum level of IL-2 of the observation group was evidently higher,while IL-10 was lower than those of the control group （P 〈 0.01 ）. Conclusion Efficacy of matrine injection combined with CAG regimen for children with acute myeloid leukemia is obvious and safe, and can increase serum level of IL-2 and decrease serum level of IL-10.
出处
《实用癌症杂志》
2018年第3期516-518,共3页
The Practical Journal of Cancer
