摘要
目的：探讨子午流注择时电温针联合艾灸治疗结肠慢传输型便秘患者的临床疗效及对肠神经递质的影响。方法：选取2016年1月—2016年12月收治的120例结肠慢传输型便秘作为该研究的研究对象,根据前瞻性、随机原则将120例患者随机分至对照组（n=60例）和观察组（n=60例）,对照组予以莫沙必利、福松等药物治疗,观察组予以子午流注择时电温针联合艾灸治疗,两组患者的治疗周期均为4周,比较治疗前后两组患者症状积分变化情况、临床疗效,并比较两组患者治疗前后血清肠神经递质一氧化氮（NO）、P物质（SP）、胃饥饿素（Ghrelin）含量的变化情况。结果：治疗后,对照组及观察组的排便间隔积分、粪便性质积分、排便费力积分、症状总积分均显著低于治疗前,且观察组显著低于对照组,均P〈0.05。对照组临床总有效率为75.00%,观察组临床总有效率为95.00%,经χ2检验,观察组的临床总有效率显著高于对照组,P〈0.05。治疗后,对照组及观察组的NO含量显著低于治疗前,且观察组下降更明显;治疗后,对照组及观察组的SP、Ghrelin含量显著高于治疗前,且观察组升高得更明显,均P〈0.05。结论：子午流注择时电温针联合艾灸法,采用时间医学理念,可有效改善结肠慢传输型便秘患者的便秘症状,其作用机制可能与双向调节机体胃肠神经递质水平的作用,提高肠道平滑肌运动相关。
Objective：To discuss the therapeutic effect and intestinal neurotransmitters of Ziwu Liuzhu timing electric acupuncture combined with moxibustion on patients with slow transit constipation.Methods：According to the principle of foresight and randomization,120 cases of colonic slow transit constipation from January 2016 to December 2016 in our hospital were assigned to the control group（n=60 cases）and observation group（n=60 cases）.Patients in the control group were treated with mosapride and forlax,and those cases in observation group were treated with Ziwu Liuzhu timing electric acupuncture combined with moxibustion.The symptom score changes,clinical efficacy,NO,SP and ghrelin content changes of two groups were compared after 4 weeks.Results：After treatment,the defecation interval score,stool quality score,defecation stamina score,symptom score were significantly lower than before treatment in both groups.And all the indicators in observation group were significantly lower than in the control group,P0.05.The total effective rate of the control group was 75%,the observation group was 95%.After χ~2 test,the total effective rate of the observation group was significantly higher than the control group,P0.05.After treatment,the NO content of both groups was significantly lower than before treatment,and the observation group decreased more significantly.And the SP and ghrelin content of both groups was significantly higher than those before treatment,the observation group increased more significantly,both P0.05.Conclusion：Adopting the concept of time medicine,Ziwu Liuzhu timing electric acupuncture combined with moxibustion can effectively improve the symptoms of patients with slow transit constipation.The mechanism may be related to the bidirectional regulation of the level of gastrointestinal neurotransmitter and the improvement of intestinal smooth muscle movement.
出处
《辽宁中医药大学学报》
CAS
2018年第2期77-80,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省自然科学基金指导计划项目(20170540627)
辽宁省教育厅一般项目(L2014370)
关键词
结肠慢传输型便秘
电温针
艾灸
子午流注择时
colonic slow transit constipation
electric acupuncture
moxibustion
Ziwu Liuzhu timing
