摘要
有关研究发现卒中后抑郁与氧化应激反应亢进密切相关,其中具体表现为与氧化应激反应相关的标志物5-HT、BDNF水平的下降及炎性因子上升密切相关,针灸可多方面调整上述标志物的水平而良性调控氧化应激反应起到显著的抗抑郁作用,但目前尚未见针刺抗卒中后抑郁具体机理分析,故该文拟从卒中后抑郁与氧化应激的关系及针刺调控氧化应激反应抗卒中后抑郁的临床和动物实验两方面进行分析,为临床和科研进一步研究针刺治疗卒中后抑郁提供更有力的科学依据和临床思路。
The study found a close correlation between post-stroke depression and hyperoxidative stress.The specific expression is related to the decrease of 5-ht,BDNF level and the increase of inflammatory factor in the markers associated with oxidative stress response.Acupuncture can adjust the level of the above markers in various ways and the benign regulation of oxidative stress response plays a significant role in antidepressant effect.However,no specific mechanism analysis of post-stroke depression in acupuncture has been seen.Therefore,this paper intends to analyze the relationship between post-stroke depression and oxidative stress and the clinical and animal studies of post-stroke depression in the treatment of post-stroke depression.To provide a more powerful scientific basis and clinical thinking for clinical and scientific research to further study the treatment of post-stroke depression.
出处
《辽宁中医药大学学报》
CAS
2018年第2期171-174,共4页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
氧化应激
针刺
卒中后抑郁
发病机制
综述
oxidative stress
acupuncture
post-stroke depression
mechanism
summary
