摘要
目的探讨左氧氟沙星治疗肺结核患者临床效果。方法选取2014年12月~2016年12月我院收治的200例肺结核患者作为研究对象,将其按照治疗方案的不同分为观察组与对照组,每组各100例,对照组患者给予异烟肼、利福平、吡嗪酰胺及乙胺丁醇治疗,观察组患者在对照组患者的治疗方案上加入左氧氟沙星,比较两组患者的症状改善情况、痰菌阴转情况、肺内病灶吸收情况及不良反应情况。结果治疗后1个月观察组患者的症状改善率(54%)明显高于对照组(38%);治疗后6个月观察组患者的症状改善率(91%)明显高于对照组(74%);治疗后1个月观察组患者的痰菌阴转率(91%)明显高于对照组(79%);治疗后6个月观察组患者的痰菌阴转率(100%)明显高于对照组(85%);观察组患者的肺内病灶吸收率(94%)明显高于对照组73%;观察组患者的不良反应发生率(20%)明显低于对照组(49%),差异均有统计学意义(P<0.05)。结论在肺结核患者中运用左氧氟沙星可明显提高临床疗效,有效改善患者症状,提高痰菌阴转率及肺内病灶吸收率,减少不良反应的发生风险,且应用范围较广,值得临床推广应用。
Objective To investigate the clinical effect of Levofloxacin in the treatment of pulmonary tuberculosis.Methotis 200 cases of tuberculosis patients treated in our hospital from December 2014 to December 2016 were selected as the study subjects,and randomly divided into observation group and control group by different treatments,100 cases in each group.Patients in the control group were treated with Isoniazid,Rifampicin,Pyrazinamide and Ethambntol.Patients in the observation group were treated with Levofloxacin based on the treatment of control group.The improvement of the symptoms,the cases of sputum negative conversion,absorption of the lung lesions and the adverse reactions of the two groups were compared.Results At 1 month after treatment,the symptom improvement rate in observation group （54%） was significantly higher than that in control group （38%）.At 6 months after treatment,the symptom improvement rate in observation group （91%） was significantly higher than that in control group （74%）.1 month after treatment,the sputum negative conversion rate in the observation group （91%） was significantly higher than that in the control group （79%）.After 6 months,the sputum negative conversion rate in observation group （100%） was significantly higher than that in the control group （85%）.The lung absorption rate in the observation group （94%） was higher than that in the control group （73%）. The incidence of dverse reactions in the observation group （20%） was significantly lower than the control group （49%）, the difference was statistically significant （P〈0.05）.Conclusion Levofloxacin in patients with pulmonary tuberculosis can significantly improve clinical efficacy,effectively improve the symptoms of patients,improve sputum negative conversion rate and intrapulmonary lesions absorption rate,reduce the risk of adverse reactions,have a wide range of applications, whicht is worthy of clinical promotion and application.
出处
《中国当代医药》
2018年第4期44-46,共3页
China Modern Medicine
关键词
肺结核
左氧氟沙星
治疗效果
Pulmonary tuberculosis
Levofloxacin
Treatment effect
