摘要
葡萄糖转运蛋白4(glucose transporter 4,GLUT4)参与胰岛素敏感的脂肪细胞和肌肉细胞中的葡萄糖转运,对机体葡萄糖代谢至关重要。磷脂酰肌醇作为各种蛋白质的定位信号,参与调控细胞生长和新陈代谢,在胰岛素信号转导过程中起着关键作用。在过去的几十年里,关于磷脂酰肌醇信号调控GLUT4囊泡转运方面已有了很大的进展。该文总结了磷脂酰肌醇在GLUT4囊泡转运中的调控作用。
Glucose transporter 4（GLUT4） is essential for the uptake of glucose into insulin-sensitive adipocytes and muscle cells and for its intracellular metabolism. Phosphatidylinositol, which works as localization signal of various proteins, plays an important role in regulation of cell growth, metabolism and insulin signaling transduction. Over the last few decades, much progress has been made on studying of the role of phosphatidylinositol signaling and GLUT4 translocation. This review summarizes the latest research on the regulatory role of phosphatidylinositol in intracellular GLUT4 vesicle trafficking.
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第1期139-145,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31571480
31611130037)
浙江省自然科学基金(批准号:LY18H070004
LR18H180001)资助的课题~~
关键词
葡萄糖转运蛋白
囊泡转运
磷脂酰肌醇
glucose transporter
vesicle trafficking
phosphafidylinositol
