摘要
有机阴离子转运蛋白(OAT)是一类底物特异性差、主要表达于屏障上皮细胞的转运蛋白,属于溶质载体超家族(SLC)。此类蛋白主要位于肾近曲小管,在其他器官如肝、脑和胎盘也有分布,主要负责内源性和外源性有机阴离子的重吸收和分泌,介导众多带负电的体内代谢产物(包括尿酸、前列腺素、神经递质酸性代谢终产物、甾体激素等)和多种药物的跨细胞膜转运,对药物的排泄和药代动力学特性有重要影响。本文就目前发现的OAT家族各亚型成员的研究进展进行综述。
Organic anion transporters（OAT）belong to a family of poly-specific transporters mainly locate in barrier epithelia such as renal proximal tubule. The solute transporter superfamily（SLC）is mainly distributed in the renal proximal convoluted tubules and located in other organs such as the brain,liver and placenta. They are mainly responsible for the reabsorption and secretion of endogenous and exogenous organic anions. OAT interact with endogenous metabolic end products such as urate and acidic neutrotransmitter metabolites,as well as a multitude of widely used drugs,and play an important role in the excretion and pharmacokinetics of drugs.This article reviews the recent progress in the research of the members of the OAT family.
出处
《国际药学研究杂志》
CSCD
北大核心
2017年第10期931-934,共4页
Journal of International Pharmaceutical Research
基金
国家自然科学基金资助项目(81360505)
云南省应用基础研究计划重点项目(2013FA017)
关键词
有机阴离子转运蛋白
转运机制
尿酸
organic anion transporters
transport mechanism
uric acid
